Robert Patrick Doyle

2001

Phenazine-2,3-diamine

Doyle, R. P., Kruger, P. E., Mackie, P. R. & Nieuwenhuyzen, M., Jan 1 2001, In : Acta Crystallographica, Section C: Crystal Structure Communications. 57, 1, p. 104-105 2 p.

Research output: Contribution to journal › Article

14 Scopus citations

Structure and magnetic properties of a pyrophosphate-bridged Cu(II) complex

Kruger, P. E., Doyle, R. P., Julve, M., Lloret, F. & Nieuwenhuyzen, M., Apr 9 2001, In : Inorganic Chemistry. 40, 8, p. 1726-1727 2 p.

Research output: Contribution to journal › Article

53 Scopus citations

2002

A dihydrogen arsenate-mediated supramolecular network: Crystal structure and magnetic properties of {|(bipy)Cu(μ-H₂AsO₄)(H ₂AsO₄)|₂}_n

Doyle, R. P., Kruger, P. E., Julve, M., Lloret, F. & Nieuwenhuyzen, M., Dec 1 2002, In : CrystEngComm. 4, 3, p. 13-16 4 p.

Research output: Contribution to journal › Article

20 Scopus citations

2003

Synthesis and structural and magnetic characterisation of tetranuclear Cu(ii) complexes possessing novel [Cu₄(μ₄-PO₄)₂(μ₂-CO₃)] butterfly cores that exhibit supramolecular isomerism

Doyle, R. P., Kruger, P. E., Moubaraki, B., Murray, K. S. & Nieuwenhuyzen, M., Nov 4 2003, In : Journal of the Chemical Society. Dalton Transactions. 3, 22, p. 4230-4237 8 p.

Research output: Contribution to journal › Article

45 Scopus citations

2005

Polynuclear complexes with bridging pyrophosphate ligands: Synthesis and characterisation of {[(bipy)Cu(H₂O)

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., Dec 7 2005, In : Dalton Transactions. 23, p. 3745-3750 6 p.

Research output: Contribution to journal › Article

36 Scopus citations

2006

A molecular 'back-flip': The structural consequences of the crystal-to-crystal phase transition between [(phen)₂CuCO ₃]·11H₂O and [(phen)₂CuCO ₃]·7H₂O

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., Nov 29 2006, In : CrystEngComm. 8, 12, p. 904-908 5 p.

Research output: Contribution to journal › Article

4 Scopus citations

Hydrogen-bond tuning of ferromagnetic interactions: Synthesis, structure and magnetic properties of polynuclear copper(II) complexes incorporating p-block oxo-anions

Doyle, R. P., Julve, M., Lloret, F., Nieuwenhuyzen, M. & Kruger, P. E., Jun 5 2006, In : Dalton Transactions. 17, p. 2081-2088 8 p.

Research output: Contribution to journal › Article

26 Scopus citations

Synthesis, structure and thermal analysis of the gallium complex of 1,4,7,10-tetraazacyclo-dodecane-N,N′,N″,N‴-tetraacetic acid (DOTA)

Viola, N. A., Rarig, R. S., Ouellette, W. & Doyle, R. P., Dec 25 2006, In : Polyhedron. 25, 18, p. 3457-3462 6 p.

Research output: Contribution to journal › Article

43 Scopus citations

2007

Metamorphosis of a butterfly: Synthesis, structural, thermal, magnetic and DFT characterisation of a ferromagnetically coupled tetranuclear copper(ii) complex

Doyle, R. P., Bauer, T., Julve, M., Lloret, F., Cano, J., Nieuwenhuyzen, M. & Kruger, P. E., Jan 1 2007, In : Dalton Transactions. 44, p. 5140-5147 8 p.

Research output: Contribution to journal › Article

16 Scopus citations

Synthesis, X-ray structure, thermal and magnetic behavior of [(bipy) ₂Ni₂(μ-Cl)₂Cl₂(H ₂O)₂]: The first neutral ferromagnetically coupled six-coordinate dichlorido-bridged nickel(II) dimer

Ikotun, O. F., Ouellette, W., Lloret, F., Julve, M. & Doyle, R. P., Jul 2 2007, In : European Journal of Inorganic Chemistry. 14, p. 2083-2088 6 p.

Research output: Contribution to journal › Article

14 Scopus citations

Synthesis and structural and magnetic characterization of {[(phen) ₂Ni]₂(μ-P₂O₇)}·27H ₂O and {[(phen)₂Mn]₂(μ-P₂O ₇)}·13H₂O: Rare examples of coordination complexes with the pyrophosphate ligand

Ikotun, O. F., Armatus, N. G., Julve, M., Kruger, P. E., Lloret, F., Nieuwenhuyzen, M. & Doyle, R. P., Aug 6 2007, In : Inorganic Chemistry. 46, 16, p. 6668-6674 7 p.

Research output: Contribution to journal › Article

38 Scopus citations

Vitamin B₁₂ as a carrier for the oral delivery of insulin

Petrus, A. K., Vortherms, A. R., Fairchild, T. J. & Doyle, R. P., Dec 10 2007, In : ChemMedChem. 2, 12, p. 1717-1721 5 p.

Research output: Contribution to journal › Article

53 Scopus citations

2008

Functional characterization and metal ion specificity of the metal-citrate complex transporter from Streptomyces coelicolor

Lensbouer, J. J., Patel, A., Sirianni, J. P. & Doyle, R. P., Aug 1 2008, In : Journal of bacteriology. 190, 16, p. 5616-5623 8 p.

Research output: Contribution to journal › Article

18 Scopus citations

On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis

Tinoco, A. D., Peterson, C. W., Lucchese, B., Doyle, R. P. & Valentine, A. M., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3268-3273 6 p.

Research output: Contribution to journal › Article

22 Scopus citations

Orthogonal ligation: A three piece assembly of a PNA-peptide-PNA conjugate

Burlina, F., Dixson, D. D., Doyle, R. P., Chassaing, G., Boddy, C. N., Dawson, P. & Offer, J., 2008, In : Chemical Communications. 24, p. 2785-2787 3 p.

Research output: Contribution to journal › Article

5 Scopus citations

Spin canting in an unprecedented three-dimensional pyrophosphate- and 2,2′-bipyrimidine-bridged cobalt(II) framework

Marino, N., Mastropietro, T. F., Armentano, D., De Munno, G., Doyle, R. P., Lloret, F. & Julve, M., Sep 29 2008, In : Dalton Transactions. 38, p. 5152-5154 3 p.

Research output: Contribution to journal › Article

34 Scopus citations

Synthesis, characterization, and in vitro assay of folic acid conjugates of 3′-azido-3′-deoxythymidine (AZT): Toward targeted AZT based anticancer therapeutics

Vortherms, A. R., Doyle, R. P., Gao, D., Debrah, O. & Sinko, P. J., Feb 1 2008, In : Nucleosides, Nucleotides and Nucleic Acids. 27, 2, p. 173-185 13 p.

Research output: Contribution to journal › Article

13 Scopus citations

Synthesis, structural, magnetic and thermal characterization of {[Cu(bipy)]₂(μ-HP₂O₇)(μ-Cl)} ·H₂O

Ikotun, O. F., Higbee, E. M., Ouellette, W., Lloret, F., Julve, M. & Doyle, R. P., Nov 1 2008, In : European Journal of Inorganic Chemistry. 33, p. 5281-5286 6 p.

Research output: Contribution to journal › Article

13 Scopus citations

Synthesis, structural, thermal and magnetic characterization of a pyrophosphato-bridged cobalt(II) complex

Ikotun, O. F., Ouellette, W., Lloret, F., Kruger, P. E., Julve, M. & Doyle, R. P., Jun 1 2008, In : European Journal of Inorganic Chemistry. 17, p. 2691-2697 7 p.

Research output: Contribution to journal › Article

26 Scopus citations

Targeting gallium to cancer cells through the folate receptor

Viola-Villegas, N., Vortherms, A. & Doyle, R. P., Jan 1 2008, In : Drug Target Insights. 2008, 3, p. 13-25 13 p.

Research output: Contribution to journal › Article

11 Scopus citations

Targeting the folate receptor (FR): Imaging and cytotoxicity of Re ^I conjugates in FR-overexpressing cancer cells

Viola-Villegas, N., Rabideau, A. E., Cesnavicious, J., Zubieta, J. & Doyle, R. P., Sep 15 2008, In : ChemMedChem. 3, 9, p. 1387-1394 8 p.

Research output: Contribution to journal › Article

59 Scopus citations

2009

Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism

Vortherms, A. R., Dang, H. N. & Doyle, R. P., May 21 2009, In : Clinical Medicine: Oncology. 2009, 3, p. 19-26 8 p.

Research output: Contribution to journal › Article

6 Scopus citations

Exploring the implications of vitamin B₁₂ conjugation to insulin on insulin receptor binding

Petrus, A. K., Allis, D. G., Smith, R. P., Fairchild, T. J. & Doyle, R. P., Mar 16 2009, In : ChemMedChem. 4, 3, p. 421-426 6 p.

Research output: Contribution to journal › Article

22 Scopus citations

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun, O. F., Higbee, E. M., Ouellette, W. & Doyle, R. P., Sep 1 2009, In : Journal of Inorganic Biochemistry. 103, 9, p. 1254-1264 11 p.

Research output: Contribution to journal › Article

41 Scopus citations

Targeting the cubilin receptor through the vitamin B₁₂ uptake pathway: Cytotoxicity and mechanistic insight through fluorescent Re(I) delivery

Viola-Villegas, N., Rabideau, A. E., Bartholoma, M., Zubieta, J. & Doyle, R. P., Aug 27 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5253-5261 9 p.

Research output: Contribution to journal › Article

60 Scopus citations

2010

Assessment of endothelial function and blood metabolite status following acute ingestion of a fructose-containing beverage

Bidwell, A. J., Holmstrup, M. E., Doyle, R. P. & Fairchild, T. J., Sep 1 2010, In : Acta Physiologica. 200, 1, p. 35-43 9 p.

Research output: Contribution to journal › Article

7 Scopus citations

Expanding monomeric pyrophosphate complexes beyond platinum

Marino, N., Vortherms, A. R., Hoffman, A. E. & Doyle, R. P., Aug 2 2010, In : Inorganic Chemistry. 49, 15, p. 6790-6792 3 p.

Research output: Contribution to journal › Article

14 Scopus citations

R161, K452 and R460 residues are vital for metal-citrate complex transport in Cit_Sc from streptomyces coelicolor

Lensbouer, J. J., Li, Q. W., Estlinbaum, M. & Doyle, R. P., May 27 2010, In : Metallomics. 2, 5, p. 342-347 6 p.

Research output: Contribution to journal › Article

4 Scopus citations

Synthesis, cytotoxicity, and insight into the mode of action of Re(CO) ₃ thymidine complexes

Bartholomä, M. D., Vortherms, A. R., Hillier, S., Ploier, B., Joyal, J., Babich, J., Doyle, R. P. & Zubieta, J., Sep 3 2010, In : ChemMedChem. 5, 9, p. 1513-1529 17 p.

Research output: Contribution to journal › Article

34 Scopus citations

The binding of vitamin B₁₂ to transcobalamin(II); Structural considerations for bioconjugate design - A molecular dynamics study

Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 1 2010, In : Molecular BioSystems. 6, 9, p. 1611-1618 8 p.

Research output: Contribution to journal › Article

10 Scopus citations

2011

A modular phase transfer and ligand exchange protocol for quantum dots

Zylstra, J., Amey, J., Miska, N. J., Pang, L., Hine, C. R., Langer, J., Doyle, R. P. & Maye, M. M., Apr 19 2011, In : Langmuir. 27, 8, p. 4371-4379 9 p.

Research output: Contribution to journal › Article

47 Scopus citations

A water soluble vitamin B₁₂-Re(I) fluorescent conjugate for cell uptake screens: Use in the confirmation of cubilin in the lung cancer line A549

Vortherms, A. R., Kahkoska, A. R., Rabideau, A. E., Zubieta, J., Andersen, L. L., Madsen, M. & Doyle, R. P., Sep 21 2011, In : Chemical Communications. 47, 35, p. 9792-9794 3 p.

Research output: Contribution to journal › Article

31 Scopus citations

Isostructural Pd^II and Pt^II pyrophosphato complexes: Polymorphism and unusual bond character in d⁸-d⁸ systems

Marino, N., Fazen, C. H., Blakemore, J. D., Incarvito, C. D., Hazari, N. & Doyle, R. P., Mar 21 2011, In : Inorganic Chemistry. 50, 6, p. 2507-2520 14 p.

Research output: Contribution to journal › Article

48 Scopus citations

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B ₁₂ uptake pathway

Fazen, C. H., Valentin, D., Fairchild, T. J. & Doyle, R. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8707-8711 5 p.

Research output: Contribution to journal › Article

26 Scopus citations

Pyrophosphate-mediated magnetic interactions in Cu(II) coordination complexes

Marino, N., Ikotun, O. F., Julve, M., Lloret, F., Cano, J. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 378-389 12 p.

Research output: Contribution to journal › Article

44 Scopus citations

Recombinant expression of His-tagged saposin B and pH-dependent binding to the lipid coenzyme Q10

Dixson, D. D., Yu, V. Y. & Doyle, R. P., Dec 15 2011, In : Analytical Biochemistry. 419, 2, p. 145-152 8 p.

Research output: Contribution to journal › Article

5 Scopus citations

Reinvestigation of coenzyme Q10 isolation from sporidiobolus johnsonii

Dixson, D. D., Boddy, C. N. & Doyle, R. P., Jun 1 2011, In : Chemistry and Biodiversity. 8, 6, p. 1033-1051 19 p.

Research output: Contribution to journal › Article

10 Scopus citations

Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)₃ thymidine complexes

Bartholomä, M. D., Vortherms, A. R., Hillier, S., Joyal, J., Babich, J., Doyle, R. P. & Zubieta, J., Jun 21 2011, In : Dalton Transactions. 40, 23, p. 6216-6225 10 p.

Research output: Contribution to journal › Article

31 Scopus citations

Synthesis and structure of a lead(II)-citrate: {Na(H₂O) ₃}[Pb₅(C₆H₅O₇) ₃(C₆H₆O₇)(H₂O) ₃]·9.5H₂O

Chu, C., Darling, K., Netusil, R., Doyle, R. P. & Zubieta, J., Nov 30 2011, In : Inorganica Chimica Acta. 378, 1, p. 186-193 8 p.

Research output: Contribution to journal › Article

6 Scopus citations

Synthetically persistent, self assembled [V ^IV ₂V ^V ₄] polyoxovanadates: Facile synthesis, structure and magnetic analysis

Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Dec 7 2011, In : Dalton Transactions. 40, 45, p. 12248-12256 9 p.

Research output: Contribution to journal › Article

17 Scopus citations

Trifluoracetic acid-assisted crystallization of vitamin B₁₂ results in protonation of the phosphate group of the nucleotide loop: Insight into the influence of crystal packing forces on vitamin B₁₂ structures

Marino, N., Rabideau, A. E. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 220-230 11 p.

Research output: Contribution to journal › Article

10 Scopus citations

2012

Examining the effects of vitamin B₁₂ conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 1 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journal › Article

10 Scopus citations

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 1 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journal › Article

5 Scopus citations

Pyro without fire: Synthesis, structure, and reactivity of a dimeric vanadyl pyrophosphate coordination complex

Marino, N., Hanson, S. K., Müller, P. & Doyle, R. P., Oct 1 2012, In : Inorganic Chemistry. 51, 19, p. 10077-10079 3 p.

Research output: Contribution to journal › Article

9 Scopus citations

Site-selective oxidation of vitamin B¹² using 2-iodoxybenzoic acid

Clardy-James, S., Bernstein, J. L., Kerwood, D. J. & Doyle, R. P., Dec 1 2012, In : Synlett. 23, 16, p. 2363-2366 4 p., ST-2012-R0524-L.

Research output: Contribution to journal › Article

10 Scopus citations

Synthesis, structural, thermal, and magnetic investigations of Co(II), Ni(II), and Mn(II) pyrophosphate chains

Hoffman, A. E., Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Jul 1 2012, In : Inorganica Chimica Acta. 389, p. 151-158 8 p.

Research output: Contribution to journal › Article

8 Scopus citations

2013

Aging-related changes in the iron status of skeletal muscle

DeRuisseau, K. C., Park, Y. M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H. & Doyle, R. P., Nov 1 2013, In : Experimental Gerontology. 48, 11, p. 1294-1302 9 p.

Research output: Contribution to journal › Article

14 Scopus citations

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Hoffman, A. E., DeStefano, M., Shoen, C., Gopinath, K., Warner, D. F., Cynamon, M. & Doyle, R. P., Jan 1 2013, In : European Journal of Medicinal Chemistry. 70, p. 589-593 5 p.

Research output: Contribution to journal › Article

26 Scopus citations

Emission wavelength variation with changes in excitation in a re(-i-)-bisthiazole ligand complex that breaks the kasha-vavilov rule

Henry, K. E., Balasingham, R. G., Vortherms, A. R., Platts, J. A., Valliant, J. F., Coogan, M. P., Zubieta, J. & Doyle, R. P., May 7 2013, In : Chemical Science. 4, 6, p. 2490-2495 6 p.

Research output: Contribution to journal › Article

23 Scopus citations

Synthesis, Characterization and Pharmacodynamics of Vitamin-B₁₂-Conjugated Glucagon-Like Peptide-1

Clardy-James, S., Chepurny, O. G., Leech, C. A., Holz, G. G. & Doyle, R. P., Apr 1 2013, In : ChemMedChem. 8, 4, p. 582-586 5 p.

Research output: Contribution to journal › Article

24 Scopus citations