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Robert Patrick Doyle

  • 1548 Citations
  • 25 h-Index
20012020
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Research Output 2001 2019

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Article
2001
14 Citations (Scopus)

Phenazine-2,3-diamine

Doyle, R. P., Kruger, P. E., Mackie, P. R. & Nieuwenhuyzen, M., Jan 2001, In : Acta Crystallographica Section C: Crystal Structure Communications. 57, 1, p. 104-105 2 p.

Research output: Contribution to journal › Article

Diamines
diamines
chemistry
nuclear magnetic resonance
hydrogen
53 Citations (Scopus)

Structure and magnetic properties of a pyrophosphate-bridged Cu(II) complex

Kruger, P. E., Doyle, R. P., Julve, M., Lloret, F. & Nieuwenhuyzen, M., Apr 9 2001, In : Inorganic Chemistry. 40, 8, p. 1726-1727 2 p.

Research output: Contribution to journal › Article

Magnetic properties
magnetic properties
aqueous solutions
salts
Salts
2002
20 Citations (Scopus)

A dihydrogen arsenate-mediated supramolecular network: Crystal structure and magnetic properties of {|(bipy)Cu(μ-H2AsO4)(H 2AsO4)|2}n

Doyle, R. P., Kruger, P. E., Julve, M., Lloret, F. & Nieuwenhuyzen, M., 2002, In : CrystEngComm. 4, 3, p. 13-16 4 p.

Research output: Contribution to journal › Article

arsenates
Magnetic susceptibility
Magnetic properties
Suspensions
Hydrogen bonds
2003
4 Citations (Scopus)

Synthesis and structural and magnetic characterisation of tetranuclear Cu(ii) complexes possessing novel [Cu4(μ4-PO4)2(μ2-CO3)] butterfly cores that exhibit supramolecular isomerism

Doyle, R. P., Kruger, P. E., Moubaraki, B., Murray, K. S. & Nieuwenhuyzen, M., Nov 4 2003, In : Journal of the Chemical Society. Dalton Transactions. 3, 22, p. 4230-4237 8 p.

Research output: Contribution to journal › Article

Water
Ice
Magnetic susceptibility
Isomers
Dimers
45 Citations (Scopus)

Synthesis and structural and magnetic characterisation of tetranuclear Cu(II) complexes possessing novel [Cu4(μ4- PO4)2-(μ2-CO3)] butterfly cores that exhibit supramolecular isomerism

Doyle, R. P., Kruger, P. E., Moubaraki, B., Murray, K. S. & Nieuwenhuyzen, M., Nov 21 2003, In : Dalton Transactions. 22, p. 4230-4237 8 p.

Research output: Contribution to journal › Article

Water
Phenanthrolines
Ice
Magnetic susceptibility
Isomers
2005
35 Citations (Scopus)

Polynuclear complexes with bridging pyrophosphate ligands: Synthesis and characterisation of {[(bipy)Cu(H2O)

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., Dec 7 2005, In : Dalton Transactions. 23, p. 3745-3750 6 p.

Research output: Contribution to journal › Article

Ligands
Water
Dimers
Inorganic Pyrophosphatase
Atoms
2006
4 Citations (Scopus)

A molecular 'back-flip': The structural consequences of the crystal-to-crystal phase transition between [(phen)2CuCO 3]·11H2O and [(phen)2CuCO 3]·7H2O

Doyle, R. P., Nieuwenhuyzen, M. & Kruger, P. E., 2006, In : CrystEngComm. 8, 12, p. 904-908 5 p.

Research output: Contribution to journal › Article

Phase transitions
Crystals
bricks
Brick
crystals
26 Citations (Scopus)

Hydrogen-bond tuning of ferromagnetic interactions: Synthesis, structure and magnetic properties of polynuclear copper(ii) complexes incorporating p-block oxo-anions

Doyle, R. P., Julve, M., Lloret, F., Nieuwenhuyzen, M. & Kruger, P. E., Apr 20 2006, In : Journal of the Chemical Society. Dalton Transactions. 17, p. 2081-2088 8 p.

Research output: Contribution to journal › Article

Anions
Copper
Magnetic properties
Hydrogen bonds
Tuning
42 Citations (Scopus)

Synthesis, structure and thermal analysis of the gallium complex of 1,4,7,10-tetraazacyclo-dodecane-N,N′,N″,N‴-tetraacetic acid (DOTA)

Viola, N. A., Rarig, R. S., Ouellette, W. & Doyle, R. P., Dec 25 2006, In : Polyhedron. 25, 18, p. 3457-3462 6 p.

Research output: Contribution to journal › Article

Gallium
Thermoanalysis
gallium
thermal analysis
Hot Temperature
2007
16 Citations (Scopus)

Metamorphosis of a butterfly: Synthesis, structural, thermal, magnetic and DFT characterisation of a ferromagnetically coupled tetranuclear copper(ii) complex

Doyle, R. P., Bauer, T., Julve, M., Lloret, F., Cano, J., Nieuwenhuyzen, M. & Kruger, P. E., 2007, In : Dalton Transactions. 44, p. 5140-5147 8 p.

Research output: Contribution to journal › Article

Discrete Fourier transforms
Copper
Water
Ligands
Molecules
13 Citations (Scopus)

Synthesis, X-ray structure, thermal and magnetic behavior of [(bipy) 2Ni2(μ-Cl)2Cl2(H 2O)2]: The first neutral ferromagnetically coupled six-coordinate dichlorido-bridged nickel(II) dimer

Ikotun, O. F., Ouellette, W., Lloret, F., Julve, M. & Doyle, R. P., 2007, In : European Journal of Inorganic Chemistry. 14, p. 2083-2088 6 p.

Research output: Contribution to journal › Article

Nickel
Dimers
X rays
Diffusion in liquids
Hamiltonians
37 Citations (Scopus)

Synthesis and structural and magnetic characterization of {[(phen) 2Ni]2(μ-P2O7)}·27H 2O and {[(phen)2Mn]2(μ-P2O 7)}·13H2O: Rare examples of coordination complexes with the pyrophosphate ligand

Ikotun, O. F., Armatus, N. G., Julve, M., Kruger, P. E., Lloret, F., Nieuwenhuyzen, M. & Doyle, R. P., Aug 6 2007, In : Inorganic Chemistry. 46, 16, p. 6668-6674 7 p.

Research output: Contribution to journal › Article

Phenanthrolines
Coordination Complexes
Ligands
ligands
metal ions
51 Citations (Scopus)

Vitamin B12 as a carrier for the oral delivery of insulin

Petrus, A. K., Vortherms, A. R., Fairchild, T. J. & Doyle, R. P., Dec 10 2007, In : ChemMedChem. 2, 12, p. 1717-1721 5 p.

Research output: Contribution to journal › Article

Vitamin B 12
Insulin
Patient Compliance
Medical problems
Oral Administration
2008
18 Citations (Scopus)

Functional characterization and metal ion specificity of the metal-citrate complex transporter from Streptomyces coelicolor

Lensbouer, J. J., Patel, A., Sirianni, J. P. & Doyle, R. P., Aug 2008, In : Journal of Bacteriology. 190, 16, p. 5616-5623 8 p.

Research output: Contribution to journal › Article

Streptomyces coelicolor
Coordination Complexes
Citric Acid
Metals
Ions
22 Citations (Scopus)

On the evolutionary significance and metal-binding characteristics of a monolobal transferrin from Ciona intestinalis

Tinoco, A. D., Peterson, C. W., Lucchese, B., Doyle, R. P. & Valentine, A. M., Mar 4 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 9, p. 3268-3273 6 p.

Research output: Contribution to journal › Article

Transferrins
Ciona intestinalis
Transferrin
Metals
Proteins
5 Citations (Scopus)

Orthogonal ligation: A three piece assembly of a PNA-peptide-PNA conjugate

Burlina, F., Dixson, D. D., Doyle, R. P., Chassaing, G., Boddy, C. N., Dawson, P. & Offer, J., 2008, In : Chemical Communications. 24, p. 2785-2787 3 p.

Research output: Contribution to journal › Article

Peptides
34 Citations (Scopus)

Spin canting in an unprecedented three-dimensional pyrophosphate- and 2,2′-bipyrimidine-bridged cobalt(ii) framework

Marino, N., Mastropietro, T. F., Armentano, D., De Munno, G., Doyle, R. P., Lloret, F. & Julve, M., Sep 23 2008, In : Journal of the Chemical Society. Dalton Transactions. 38, p. 5152-5154 3 p.

Research output: Contribution to journal › Article

Cobalt compounds
Cobalt
Ligands
diphosphoric acid
13 Citations (Scopus)

Synthesis, characterization, and in vitro assay of folic acid conjugates of 3′-azido-3′-deoxythymidine (AZT): Toward targeted AZT based anticancer therapeutics

Vortherms, A. R., Doyle, R. P., Gao, D., Debrah, O. & Sinko, P. J., Feb 2008, In : Nucleosides, Nucleotides and Nucleic Acids. 27, 2, p. 173-185 13 p.

Research output: Contribution to journal › Article

Zidovudine
Folic Acid
Assays
Cells
Cell Line
13 Citations (Scopus)

Synthesis, structural, magnetic and thermal characterization of {[Cu(bipy)]2(μ-HP2O7)(μ-Cl)} ·H2O

Ikotun, O. F., Higbee, E. M., Ouellette, W., Lloret, F., Julve, M. & Doyle, R. P., Nov 2008, In : European Journal of Inorganic Chemistry. 33, p. 5281-5286 6 p.

Research output: Contribution to journal › Article

Copper
Hamiltonians
Magnetic couplings
Atoms
Molecular interactions
26 Citations (Scopus)

Synthesis, structural, thermal and magnetic characterization of a pyrophosphato-bridged cobalt(II) complex

Ikotun, O. F., Ouellette, W., Lloret, F., Kruger, P. E., Julve, M. & Doyle, R. P., Jun 2008, In : European Journal of Inorganic Chemistry. 17, p. 2691-2697 7 p.

Research output: Contribution to journal › Article

Cobalt
Ligands
Magnetic susceptibility
Metals
Magnetic couplings
11 Citations (Scopus)

Targeting gallium to cancer cells through the folate receptor

Viola-Villegas, N., Vortherms, A. & Doyle, R. P., 2008, In : Drug Target Insights. 2008, 3, p. 13-25 13 p.

Research output: Contribution to journal › Article

Gallium
Folic Acid
Cells
Polyethylene glycols
Neoplasms
56 Citations (Scopus)

Targeting the folate receptor (FR): Imaging and cytotoxicity of Re I conjugates in FR-overexpressing cancer cells

Viola-Villegas, N., Rabideau, A. E., Cesnavicious, J., Zubieta, J. A. & Doyle, R. P., Sep 15 2008, In : ChemMedChem. 3, 9, p. 1387-1394 8 p.

Research output: Contribution to journal › Article

Cytotoxicity
Folic Acid
Cells
Imaging techniques
Rhenium
2009
6 Citations (Scopus)

Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism

Vortherms, A. R., Dang, H. N. & Doyle, R. P., 2009, In : Clinical Medicine: Oncology. 2009, 3, p. 19-26 8 p.

Research output: Contribution to journal › Article

Idoxuridine
Nucleosides
Methotrexate
Zalcitabine
Inhibitory Concentration 50
21 Citations (Scopus)

Exploring the implications of vitamin B12 conjugation to insulin on insulin receptor binding

Petrus, A. K., Allis, D. G., Smith, R. P., Fairchild, T. J. & Doyle, R. P., Mar 16 2009, In : ChemMedChem. 4, 3, p. 421-426 6 p.

Research output: Contribution to journal › Article

Insulin Receptor
Vitamin B 12
Insulin
Chemical modification
Blood Glucose
40 Citations (Scopus)

Pyrophosphate-bridged complexes with picomolar toxicity

Ikotun, O. F., Higbee, E. M., Ouellette, W. & Doyle, R. P., Sep 2009, In : Journal of Inorganic Biochemistry. 103, 9, p. 1254-1264 11 p.

Research output: Contribution to journal › Article

Toxicity
Cytotoxicity
Hydrolysis
Cells
Enzyme inhibition
56 Citations (Scopus)

Targeting the cubilin receptor through the vitamin B12 uptake pathway: Cytotoxicity and mechanistic insight through fluorescent Re(I) delivery

Viola-Villegas, N., Rabideau, A. E., Bartholoma, M., Zubieta, J. A. & Doyle, R. P., Aug 27 2009, In : Journal of Medicinal Chemistry. 52, 16, p. 5253-5261 9 p.

Research output: Contribution to journal › Article

Vitamin B 12
Intrinsic Factor
Rhenium
Choriocarcinoma
Biosensing Techniques
89 Citations (Scopus)

The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships

Viola-Villegas, N. & Doyle, R. P., Jul 2009, In : Coordination Chemistry Reviews. 253, 13-14, p. 1906-1925 20 p.

Research output: Contribution to journal › Article

Metal complexes
acetic acid
Acetic acid
Acetic Acid
Contrast Media
89 Citations (Scopus)

Traveling the vitamin B12 pathway: Oral delivery of protein and peptide drugs

Petrus, A. K., Fairchild, T. J. & Doyle, R. P., Jan 26 2009, In : Angewandte Chemie (International Edition in English). 48, 6, p. 1022-1028 7 p.

Research output: Contribution to journal › Article

Vitamins
Vitamin B 12
Peptides
Proteins
Pharmaceutical Preparations
2010
7 Citations (Scopus)

Assessment of endothelial function and blood metabolite status following acute ingestion of a fructose-containing beverage

Bidwell, A. J., Holmstrup, M. E., Doyle, R. P. & Fairchild, T. J., Sep 2010, In : Acta Physiologica. 200, 1, p. 35-43 9 p.

Research output: Contribution to journal › Article

Beverages
Fructose
Eating
Glucose
Uric Acid
38 Citations (Scopus)

Coordination complexes incorporating pyrophosphate: Structural overview and exploration of their diverse magnetic, catalytic and biological properties

Ikotun, O. F., Marino, N., Kruger, P. E., Julve, M. & Doyle, R. P., Apr 2010, In : Coordination Chemistry Reviews. 254, 7-8, p. 890-915 26 p.

Research output: Contribution to journal › Article

Coordination Complexes
Negative ions
Ligands
magnetic properties
Biochemistry
14 Citations (Scopus)

Expanding monomeric pyrophosphate complexes beyond platinum

Marino, N., Vortherms, A. R., Hoffman, A. E. & Doyle, R. P., Aug 2 2010, In : Inorganic Chemistry. 49, 15, p. 6790-6792 3 p.

Research output: Contribution to journal › Article

Platinum
cultured cells
Stoichiometry
Doxorubicin
Cisplatin
4 Citations (Scopus)

R161, K452 and R460 residues are vital for metal-citrate complex transport in CitSc from streptomyces coelicolor

Lensbouer, J. J., Li, Q. W., Estlinbaum, M. & Doyle, R. P., 2010, In : Metallomics. 2, 5, p. 342-347 6 p.

Research output: Contribution to journal › Article

Streptomyces coelicolor
Coordination Complexes
Citric Acid
Metals
Membrane Transport Proteins
9 Citations (Scopus)

Secondary transport of metalcitrate complexes: The CitMHS family

Lensbouer, J. J. & Doyle, R. P., Oct 2010, In : Critical Reviews in Biochemistry and Molecular Biology. 45, 5, p. 453-462 10 p.

Research output: Contribution to journal › Article

Metal ions
Bacteria
Bioremediation
Citric Acid
Escherichia coli
32 Citations (Scopus)

Synthesis, cytotoxicity, and insight into the mode of action of Re(CO) 3 thymidine complexes

Bartholomä, M. D., Vortherms, A. R., Hillier, S., Ploier, B., Joyal, J., Babich, J., Doyle, R. P. & Zubieta, J. A., Sep 3 2010, In : ChemMedChem. 5, 9, p. 1513-1529 17 p.

Research output: Contribution to journal › Article

Carbon Monoxide
Cytotoxicity
Thymidine
Toxicity
Nucleosides
10 Citations (Scopus)

The binding of vitamin B12 to transcobalamin(II); Structural considerations for bioconjugate design - A molecular dynamics study

Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 2010, In : Molecular BioSystems. 6, 9, p. 1611-1618 8 p.

Research output: Contribution to journal › Article

Transcobalamins
Molecular Dynamics Simulation
Vitamin B 12
Insulin
Ribose
2011
45 Citations (Scopus)

A modular phase transfer and ligand exchange protocol for quantum dots

Zylstra, J., Amey, J., Miska, N. J., Pang, L., Hine, C. R., Langer, J., Doyle, R. P. & Maye, M. M., Apr 19 2011, In : Langmuir. 27, 8, p. 4371-4379 9 p.

Research output: Contribution to journal › Article

Semiconductor quantum dots
Ligands
quantum dots
histidine
ligands
28 Citations (Scopus)

A water soluble vitamin B 12-Re(I) fluorescent conjugate for cell uptake screens: Use in the confirmation of cubilin in the lung cancer line A549

Vortherms, A. R., Kahkoska, A. R., Rabideau, A. E., Zubieta, J. A., Andersen, L. L., Madsen, M. & Doyle, R. P., Sep 21 2011, In : Chemical Communications. 47, 35, p. 9792-9794 3 p.

Research output: Contribution to journal › Article

Vitamins
Vitamin B 12
Cells
Rhenium
Intrinsic Factor
47 Citations (Scopus)

Isostructural Pd II and Pt II pyrophosphato complexes: Polymorphism and unusual bond character in d 8-d 8 systems

Marino, N., Fazen, C. H., Blakemore, J. D., Incarvito, C. D., Hazari, N. & Doyle, R. P., Mar 21 2011, In : Inorganic Chemistry. 50, 6, p. 2507-2520 14 p.

Research output: Contribution to journal › Article

polymorphism
Polymorphism
Crystals
crystals
Water
25 Citations (Scopus)

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Fazen, C. H., Valentin, D., Fairchild, T. J. & Doyle, R. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8707-8711 5 p.

Research output: Contribution to journal › Article

Appetite Regulation
Appetite
Vitamin B 12
Weight Loss
Peptides
41 Citations (Scopus)

Pyrophosphate-mediated magnetic interactions in Cu(II) coordination complexes

Marino, N., Ikotun, O. F., Julve, M., Lloret, F., Cano, J. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 378-389 12 p.

Research output: Contribution to journal › Article

Coordination Complexes
amines
Amines
interactions
metals
5 Citations (Scopus)

Recombinant expression of His-tagged saposin B and pH-dependent binding to the lipid coenzyme Q10

Dixson, D. D., Yu, V. Y. & Doyle, R. P., Dec 15 2011, In : Analytical Biochemistry. 419, 2, p. 145-152 8 p.

Research output: Contribution to journal › Article

coenzyme Q10
Saposins
Lipids
Affinity chromatography
9 Citations (Scopus)

Reinvestigation of coenzyme Q10 isolation from sporidiobolus johnsonii

Dixson, D. D., Boddy, C. N. & Doyle, R. P., Jun 2011, In : Chemistry and Biodiversity. 8, 6, p. 1033-1051 19 p.

Research output: Contribution to journal › Article

coenzyme Q10
Coenzymes
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Thin layer chromatography
Biosynthesis
30 Citations (Scopus)

Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes

Bartholomä, M. D., Vortherms, A. R., Hillier, S., Joyal, J., Babich, J., Doyle, R. P. & Zubieta, J. A., Jun 21 2011, In : Dalton Transactions. 40, 23, p. 6216-6225 10 p.

Research output: Contribution to journal › Article

Carbon Monoxide
Cytotoxicity
Thymidine
Nucleosides
Nuclear magnetic resonance spectroscopy
6 Citations (Scopus)

Synthesis and structure of a lead(II)-citrate: {Na(H 2O) 3}[Pb 5(C 6H 5O 7) 3(C 6H 6O 7)(H 2O) 3]·9.5H 2O

Chu, C., Darling, K., Netusil, R., Doyle, R. P. & Zubieta, J. A., Nov 30 2011, In : Inorganica Chimica Acta. 378, 1, p. 186-193 8 p.

Research output: Contribution to journal › Article

citrates
Citric Acid
Lead
Oxygen
Ligands
16 Citations (Scopus)

Synthetically persistent, self assembled [V IV 2V V 4] polyoxovanadates: Facile synthesis, structure and magnetic analysis

Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Dec 7 2011, In : Dalton Transactions. 40, 45, p. 12248-12256 9 p.

Research output: Contribution to journal › Article

Crystals
Vanadates
Crystallization
Modulators
Thermogravimetric analysis
10 Citations (Scopus)

Trifluoracetic acid-assisted crystallization of vitamin B12 results in protonation of the phosphate group of the nucleotide loop: Insight into the influence of crystal packing forces on vitamin B12 structures

Marino, N., Rabideau, A. E. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 220-230 11 p.

Research output: Contribution to journal › Article

cyanocobalamin
vitamins
Protonation
nucleotides
Vitamin B 12
57 Citations (Scopus)

Vitamin B12 in drug delivery: Breaking through the barriers to a B12 bioconjugate pharmaceutical

Clardy, S. M., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Jan 2011, In : Expert Opinion on Drug Delivery. 8, 1, p. 127-140 14 p.

Research output: Contribution to journal › Article

Vitamin B 12
Pharmaceutical Preparations
Micronutrients
Mammals
Insulin
2012
10 Citations (Scopus)

Examining the effects of vitamin B12 conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journal › Article

Molecular Dynamics Simulation
Vitamin B 12
Bioactivity
Molecular dynamics
Insulin
5 Citations (Scopus)

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journal › Article

Ubiquitin
Peptide Hydrolases
Escherichia coli
Digestion
Factor Xa
8 Citations (Scopus)

Metal-citrate complex uptake and CitMHS transporters: From coordination chemistry to possible vaccine development

Huta, B., Lensboeur, J. J., Lowe, A. J., Zubieta, J. A. & Doyle, R. P., Dec 1 2012, In : Inorganica Chimica Acta. 393, p. 125-134 10 p.

Research output: Contribution to journal › Article

vaccines
transporter
Vaccines
citrates
Citric Acid