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20012020

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2020

A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models

Borner, T., Shaulson, E. D., Tinsley, I. C., Stein, L. M., Horn, C. C., Hayes, M. R., Doyle, R. P. & De Jonghe, B. C., 2020, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Open Access

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Borner, T., Workinger, J. L., Tinsley, I. C., Fortin, S. M., Stein, L. M., Chepurny, O. G., Holz, G. G., Wierzba, A. J., Gryko, D., Nexø, E., Shaulson, E. D., Bamezai, A., Da Silva, V. A. R., De Jonghe, B. C., Hayes, M. R. & Doyle, R. P., Jun 16 2020, In : Cell Reports. 31, 11, 107768.

Research output: Contribution to journalArticle

Open Access

Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation

Stein, L. M., Lhamo, R., Cao, A., Workinger, J., Tinsley, I., Doyle, R. P., Grill, H. J., Hermann, G. E., Rogers, R. C. & Hayes, M. R., Dec 1 2020, In : Translational Psychiatry. 10, 1, 90.

Research output: Contribution to journalArticle

Open Access

GDF15 Induces Anorexia through Nausea and Emesis

Borner, T., Shaulson, E. D., Ghidewon, M. Y., Barnett, A. B., Horn, C. C., Doyle, R. P., Grill, H. J., Hayes, M. R. & De Jonghe, B. C., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 351-362.e5

Research output: Contribution to journalArticle

4 Scopus citations
2019

A methylenediphosphonate bridged copper(II) tetramer: Synthesis, structural, thermal, and magnetic characterization of [Cu4(H2O)2(phen)4(μ-P2O6CH2)2]·21H2O

Greenfield, T. J., Takemoto, T., Cano, J., Lloret, F., Julve, M., Zubieta, J. A. & Doyle, R. P., Sep 1 2019, In : Polyhedron. 169, p. 162-168 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Defining the origins of multiple emission/excitation in rhenium-bisthiazole complexes

Azzarelli, N., Ponnala, S., Aguirre, A., Dampf, S. J., Davis, M. P., Ruggiero, M. T., Lopez Diaz, V., Babich, J. W., Coogan, M., Korter, T., Doyle, R. P. & Zubieta, J., Apr 1 2019, In : Inorganica Chimica Acta. 489, p. 301-309 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Chepurny, O. G., Matsoukas, M. T., Liapakis, G., Leech, C. A., Milliken, B. T., Doyle, R. P. & Holz, G. G., Mar 8 2019, In : Journal of Biological Chemistry. 294, 10, p. 3514-3531 18 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Synthesis, structure and magnetic properties of a binuclear Co(II)-pyrophosphate complex, [Co2(phenanthroline-dione)4(P2O7)]

Zito, E., Greenfield, T. J., Minichelli, J., Nanao, M., Turnbull, M. M., Doyle, R. P. & Zubieta, J. A., Sep 15 2019, In : Polyhedron. 170, p. 705-711 7 p.

Research output: Contribution to journalArticle

Synthesis and structural and magnetic characterization of an Iron(III) pyrophosphate complex with 1,10′-phenanthroline

Greenfield, T. J., Turnbull, M. M., Zubieta, J. & Doyle, R. P., Dec 1 2019, In : Inorganica Chimica Acta. 498, 119084.

Research output: Contribution to journalArticle

Systemically Administered Plant Recombinant Holo-Intrinsic Factor Targets the Liver and is not Affected by Endogenous B12 levels

Workinger, J. L., Kuda-Wedagedara, A. N. W., Julin, M. M., White, J. M., Nexo, E., Viola, N. T. & Doyle, R. P., Dec 1 2019, In : Scientific reports. 9, 1, 12269.

Research output: Contribution to journalArticle

Open Access
2018

A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents

Mietlicki-Baase, E. G., Liberini, C. G., Workinger, J. L., Bonaccorso, R. L., Borner, T., Reiner, D. J., Koch-Laskowski, K., McGrath, L. E., Lhamo, R., Stein, L. M., De Jonghe, B. C., Holz, G. G., Roth, C. L., Doyle, R. P. & Hayes, M. R., May 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Dec 1 2018, In : Scientific reports. 8, 1, 3749.

Research output: Contribution to journalArticle

6 Scopus citations

Metal-citrate complex transport in Kineococcus radiotolerans

Huta, B. P., Miller, N. H., Robertson, E. L. & Doyle, R. P., Mar 2018, In : Journal of Basic Microbiology. 58, 3, p. 209-216 8 p.

Research output: Contribution to journalArticle

Recombinant manganese peroxidase reduces A2E burden in age-related and stargardt's macular degeneration models

Moody, K. J., Tinklepaugh, J., Obert, E., Grohn, K., Derosa, J. R., Lumen, E., Moyer, B. S., Campbell, S., Wolfe, A. J., Sleeper, M. B., Bianchi, A. H., Fisher, C., Applegate, J., Leary, E., Leclair, N., Wortel, D., Doyle, R. P., Rohrer, B. & Blanden, A. R., Dec 1 2018, In : Rejuvenation Research. 21, 6, p. 560-571 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

89Zr-Cobalamin PET Tracer: Synthesis, cellular uptake, and use for tumor imaging

Kuda-Wedagedara, A. N. W., Workinger, J. L., Nexo, E., Doyle, R. P. & Viola-Villegas, N., Jan 1 2017, In : ACS Omega. 2, 10, p. 6314-6320 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Exploring the multiligand binding specificity of saposin B reveals two binding sites

Tinklepaugh, J., Smith, B. M., Hanlon, E., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., Jan 1 2017, In : ACS Omega. 2, 10, p. 7141-7145 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Just a Gut Feeling: Central Nervous Effects of Peripheral Gastrointestinal Hormones

Roth, C. L. & Doyle, R. P., Jan 1 2017, In : Endocrine Development. 32, p. 100-123 24 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36)

Henry, K. E., Kerwood, D. J., Allis, D. G., Workinger, J. L., Bonaccorso, R. L., Holz, G. G., Roth, C. L., Zubieta, J. & Doyle, R. P., May 6 2016, In : ChemMedChem. 11, 9, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Lysosomal Protein Saposin B Binds Chloroquine

Huta, B. P., Mehlenbacher, M. R., Nie, Y., Lai, X., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., Feb 4 2016, In : ChemMedChem. 11, 3, p. 277-282 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline

Hoffman, A. E., Miles, L., Greenfield, T. J., Shoen, C., Destefano, M., Cynamon, M. & Doyle, R. P., Apr 1 2015, In : BioMetals. 28, 2, p. 415-423 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4

Bonaccorso, R. L., Chepurny, O. G., Becker-Pauly, C., Holz, G. G. & Doyle, R. P., Sep 8 2015, In : Molecular Pharmaceutics. 12, 9, p. 3502-3506 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ferromagnetic Coupling in "Double-Bridged" Dihydrogenpyrophosphate Complexes of Cobalt(II) and Nickel(II)

Greenfield, T. J., Hoffman, A. E., Marino, N., Goos, A. G., Lloret, F., Julve, M. & Doyle, R. P., Jul 6 2015, In : Inorganic Chemistry. 54, 13, p. 6537-6546 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Vitamin B12 conjugation of peptide-YY3-36 decreases food intake compared to native peptide-YY3-36 upon subcutaneous administration in male rats

Henry, K. E., Elfers, C. T., Burke, R. M., Chepurny, O. G., Holz, G. G., Blevins, J. E., Roth, C. L. & Doyle, R. P., May 1 2015, In : Endocrinology. 156, 5, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Investigation of a vitamin B12 conjugate as a PET imaging probe

Ikotun, O. F., Marquez, B. V., Fazen, C. H., Kahkoska, A. R., Doyle, R. P. & Lapi, S. E., Jun 2014, In : ChemMedChem. 9, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

The antimalarial drug atovaquone binds to saposin B with comparable affinity to coenzyme Q10

Huta, B. P., Roberts, A. M., Waters, E. S., Yu, V. Y., Doyle, R. P., Mehlenbacher, M. R. & Bou-Abdallah, F., Jun 2014, In : MedChemComm. 5, 6, p. 787-791 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Aging-related changes in the iron status of skeletal muscle

DeRuisseau, K. C., Park, Y. M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H. & Doyle, R. P., Nov 1 2013, In : Experimental Gerontology. 48, 11, p. 1294-1302 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Hoffman, A. E., DeStefano, M., Shoen, C., Gopinath, K., Warner, D. F., Cynamon, M. & Doyle, R. P., Jan 1 2013, In : European Journal of Medicinal Chemistry. 70, p. 589-593 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Emission wavelength variation with changes in excitation in a re(-i-)-bisthiazole ligand complex that breaks the kasha-vavilov rule

Henry, K. E., Balasingham, R. G., Vortherms, A. R., Platts, J. A., Valliant, J. F., Coogan, M. P., Zubieta, J. & Doyle, R. P., May 7 2013, In : Chemical Science. 4, 6, p. 2490-2495 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Clardy-James, S., Chepurny, O. G., Leech, C. A., Holz, G. G. & Doyle, R. P., Apr 1 2013, In : ChemMedChem. 8, 4, p. 582-586 5 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Examining the effects of vitamin B12 conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 1 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 1 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pyro without fire: Synthesis, structure, and reactivity of a dimeric vanadyl pyrophosphate coordination complex

Marino, N., Hanson, S. K., Müller, P. & Doyle, R. P., Oct 1 2012, In : Inorganic Chemistry. 51, 19, p. 10077-10079 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Site-selective oxidation of vitamin B12 using 2-iodoxybenzoic acid

Clardy-James, S., Bernstein, J. L., Kerwood, D. J. & Doyle, R. P., Dec 1 2012, In : Synlett. 23, 16, p. 2363-2366 4 p., ST-2012-R0524-L.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis, structural, thermal, and magnetic investigations of Co(II), Ni(II), and Mn(II) pyrophosphate chains

Hoffman, A. E., Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Jul 1 2012, In : Inorganica Chimica Acta. 389, p. 151-158 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

A modular phase transfer and ligand exchange protocol for quantum dots

Zylstra, J., Amey, J., Miska, N. J., Pang, L., Hine, C. R., Langer, J., Doyle, R. P. & Maye, M. M., Apr 19 2011, In : Langmuir. 27, 8, p. 4371-4379 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

A water soluble vitamin B12-Re(I) fluorescent conjugate for cell uptake screens: Use in the confirmation of cubilin in the lung cancer line A549

Vortherms, A. R., Kahkoska, A. R., Rabideau, A. E., Zubieta, J., Andersen, L. L., Madsen, M. & Doyle, R. P., Sep 21 2011, In : Chemical Communications. 47, 35, p. 9792-9794 3 p.

Research output: Contribution to journalArticle

31 Scopus citations

Isostructural PdII and PtII pyrophosphato complexes: Polymorphism and unusual bond character in d8-d8 systems

Marino, N., Fazen, C. H., Blakemore, J. D., Incarvito, C. D., Hazari, N. & Doyle, R. P., Mar 21 2011, In : Inorganic Chemistry. 50, 6, p. 2507-2520 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Fazen, C. H., Valentin, D., Fairchild, T. J. & Doyle, R. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8707-8711 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Pyrophosphate-mediated magnetic interactions in Cu(II) coordination complexes

Marino, N., Ikotun, O. F., Julve, M., Lloret, F., Cano, J. & Doyle, R. P., Jan 3 2011, In : Inorganic Chemistry. 50, 1, p. 378-389 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Recombinant expression of His-tagged saposin B and pH-dependent binding to the lipid coenzyme Q10

Dixson, D. D., Yu, V. Y. & Doyle, R. P., Dec 15 2011, In : Analytical Biochemistry. 419, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Reinvestigation of coenzyme Q10 isolation from sporidiobolus johnsonii

Dixson, D. D., Boddy, C. N. & Doyle, R. P., Jun 1 2011, In : Chemistry and Biodiversity. 8, 6, p. 1033-1051 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes

Bartholomä, M. D., Vortherms, A. R., Hillier, S., Joyal, J., Babich, J., Doyle, R. P. & Zubieta, J., Jun 21 2011, In : Dalton Transactions. 40, 23, p. 6216-6225 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Synthesis and structure of a lead(II)-citrate: {Na(H2O) 3}[Pb5(C6H5O7) 3(C6H6O7)(H2O) 3]·9.5H2O

Chu, C., Darling, K., Netusil, R., Doyle, R. P. & Zubieta, J., Nov 30 2011, In : Inorganica Chimica Acta. 378, 1, p. 186-193 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Synthetically persistent, self assembled [V IV 2V V 4] polyoxovanadates: Facile synthesis, structure and magnetic analysis

Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Dec 7 2011, In : Dalton Transactions. 40, 45, p. 12248-12256 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
10 Scopus citations
2010

Assessment of endothelial function and blood metabolite status following acute ingestion of a fructose-containing beverage

Bidwell, A. J., Holmstrup, M. E., Doyle, R. P. & Fairchild, T. J., Sep 1 2010, In : Acta Physiologica. 200, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Expanding monomeric pyrophosphate complexes beyond platinum

Marino, N., Vortherms, A. R., Hoffman, A. E. & Doyle, R. P., Aug 2 2010, In : Inorganic Chemistry. 49, 15, p. 6790-6792 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

R161, K452 and R460 residues are vital for metal-citrate complex transport in CitSc from streptomyces coelicolor

Lensbouer, J. J., Li, Q. W., Estlinbaum, M. & Doyle, R. P., May 27 2010, In : Metallomics. 2, 5, p. 342-347 6 p.

Research output: Contribution to journalArticle

4 Scopus citations