• 1642 Citations
  • 25 h-Index
20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models

Borner, T., Shaulson, E. D., Tinsley, I. C., Stein, L. M., Horn, C. C., Hayes, M. R., Doyle, R. P. & De Jonghe, B. C., 2020, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Open Access

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Borner, T., Workinger, J. L., Tinsley, I. C., Fortin, S. M., Stein, L. M., Chepurny, O. G., Holz, G. G., Wierzba, A. J., Gryko, D., Nexø, E., Shaulson, E. D., Bamezai, A., Da Silva, V. A. R., De Jonghe, B. C., Hayes, M. R. & Doyle, R. P., Jun 16 2020, In : Cell Reports. 31, 11, 107768.

Research output: Contribution to journalArticle

Open Access

Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation

Stein, L. M., Lhamo, R., Cao, A., Workinger, J., Tinsley, I., Doyle, R. P., Grill, H. J., Hermann, G. E., Rogers, R. C. & Hayes, M. R., Dec 1 2020, In : Translational Psychiatry. 10, 1, 90.

Research output: Contribution to journalArticle

Open Access

GDF15 Induces Anorexia through Nausea and Emesis

Borner, T., Shaulson, E. D., Ghidewon, M. Y., Barnett, A. B., Horn, C. C., Doyle, R. P., Grill, H. J., Hayes, M. R. & De Jonghe, B. C., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 351-362.e5

Research output: Contribution to journalArticle

4 Scopus citations
2019

A methylenediphosphonate bridged copper(II) tetramer: Synthesis, structural, thermal, and magnetic characterization of [Cu4(H2O)2(phen)4(μ-P2O6CH2)2]·21H2O

Greenfield, T. J., Takemoto, T., Cano, J., Lloret, F., Julve, M., Zubieta, J. A. & Doyle, R. P., Sep 1 2019, In : Polyhedron. 169, p. 162-168 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access
1 Scopus citations

Defining the origins of multiple emission/excitation in rhenium-bisthiazole complexes

Azzarelli, N., Ponnala, S., Aguirre, A., Dampf, S. J., Davis, M. P., Ruggiero, M. T., Lopez Diaz, V., Babich, J. W., Coogan, M., Korter, T., Doyle, R. P. & Zubieta, J., Apr 1 2019, In : Inorganica Chimica Acta. 489, p. 301-309 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exploring the biological, catalytic, and magnetic properties of transition metal coordination complexes incorporating pyrophosphate

Greenfield, T. J., Julve, M. & Doyle, R. P., Apr 1 2019, In : Coordination Chemistry Reviews. 384, p. 37-64 28 p.

Research output: Contribution to journalReview article

10 Scopus citations

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Chepurny, O. G., Matsoukas, M. T., Liapakis, G., Leech, C. A., Milliken, B. T., Doyle, R. P. & Holz, G. G., Mar 8 2019, In : Journal of Biological Chemistry. 294, 10, p. 3514-3531 18 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Synthesis, structure and magnetic properties of a binuclear Co(II)-pyrophosphate complex, [Co2(phenanthroline-dione)4(P2O7)]

Zito, E., Greenfield, T. J., Minichelli, J., Nanao, M., Turnbull, M. M., Doyle, R. P. & Zubieta, J. A., Sep 15 2019, In : Polyhedron. 170, p. 705-711 7 p.

Research output: Contribution to journalArticle

Synthesis and structural and magnetic characterization of an Iron(III) pyrophosphate complex with 1,10′-phenanthroline

Greenfield, T. J., Turnbull, M. M., Zubieta, J. & Doyle, R. P., Dec 1 2019, In : Inorganica Chimica Acta. 498, 119084.

Research output: Contribution to journalArticle

Systemically Administered Plant Recombinant Holo-Intrinsic Factor Targets the Liver and is not Affected by Endogenous B12 levels

Workinger, J. L., Kuda-Wedagedara, A. N. W., Julin, M. M., White, J. M., Nexo, E., Viola, N. T. & Doyle, R. P., Dec 1 2019, In : Scientific reports. 9, 1, 12269.

Research output: Contribution to journalArticle

Open Access
2018

A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents

Mietlicki-Baase, E. G., Liberini, C. G., Workinger, J. L., Bonaccorso, R. L., Borner, T., Reiner, D. J., Koch-Laskowski, K., McGrath, L. E., Lhamo, R., Stein, L. M., De Jonghe, B. C., Holz, G. G., Roth, C. L., Doyle, R. P. & Hayes, M. R., May 2018, In : Diabetes, Obesity and Metabolism. 20, 5, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Challenges in the diagnosis of magnesium status

Workinger, J. L., Doyle, R. P. & Bortz, J., Sep 1 2018, In : Nutrients. 10, 9, 1202.

Research output: Contribution to journalReview article

10 Scopus citations

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Dec 1 2018, In : Scientific reports. 8, 1, 3749.

Research output: Contribution to journalArticle

6 Scopus citations

Erratum: Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors (Scientific reports (2018) 8 1 (3749))

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Apr 13 2018, In : Scientific reports. 8, 1, 1 p., 6192.

Research output: Contribution to journalComment/debate

Open Access

Metal-citrate complex transport in Kineococcus radiotolerans

Huta, B. P., Miller, N. H., Robertson, E. L. & Doyle, R. P., Mar 2018, In : Journal of Basic Microbiology. 58, 3, p. 209-216 8 p.

Research output: Contribution to journalArticle

Peptide Coagonists of the GLP-1 and NPY-2 Receptors

Doyle, R. & Bonaccorso, R., Oct 30 2018, Patent No. 10,111,932

Research output: Patent

Recombinant manganese peroxidase reduces A2E burden in age-related and stargardt's macular degeneration models

Moody, K. J., Tinklepaugh, J., Obert, E., Grohn, K., Derosa, J. R., Lumen, E., Moyer, B. S., Campbell, S., Wolfe, A. J., Sleeper, M. B., Bianchi, A. H., Fisher, C., Applegate, J., Leary, E., Leclair, N., Wortel, D., Doyle, R. P., Rohrer, B. & Blanden, A. R., Dec 1 2018, In : Rejuvenation Research. 21, 6, p. 560-571 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

89Zr-Cobalamin PET Tracer: Synthesis, cellular uptake, and use for tumor imaging

Kuda-Wedagedara, A. N. W., Workinger, J. L., Nexo, E., Doyle, R. P. & Viola-Villegas, N., Jan 1 2017, In : ACS Omega. 2, 10, p. 6314-6320 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Compositions and Methods for Enhancing Peptide Stability Against Protease Digestion

Hermelin, D. S., Bortz, J. D. & Doyle, R., Nov 20 2017

Research output: Patent

Exploring the multiligand binding specificity of saposin B reveals two binding sites

Tinklepaugh, J., Smith, B. M., Hanlon, E., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., 2017, In : ACS Omega. 2, 10, p. 7141-7145 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Just a Gut Feeling: Central Nervous Effects of Peripheral Gastrointestinal Hormones

Roth, C. L. & Doyle, R. P., Jan 1 2017, In : Endocrine Development. 32, p. 100-123 24 p.

Research output: Contribution to journalArticle

4 Scopus citations

Vitamin B12 and drug development

Workinger, J. L. & Doyle, R. P., Jan 1 2017, Vitamin B12: Advances and Insights. CRC Press, p. 338-364 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Methods and Systems for Zinc Delivery Using Intrinsic Factor or Haptocorrin

Doyle, R., Mar 24 2016, Patent No. 9,505,825

Research output: Patent

Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36)

Henry, K. E., Kerwood, D. J., Allis, D. G., Workinger, J. L., Bonaccorso, R. L., Holz, G. G., Roth, C. L., Zubieta, J. & Doyle, R. P., May 6 2016, In : ChemMedChem. 11, 9, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Lysosomal Protein Saposin B Binds Chloroquine

Huta, B. P., Mehlenbacher, M. R., Nie, Y., Lai, X., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., Feb 4 2016, In : ChemMedChem. 11, 3, p. 277-282 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline

Hoffman, A. E., Miles, L., Greenfield, T. J., Shoen, C., Destefano, M., Cynamon, M. & Doyle, R. P., Apr 1 2015, In : BioMetals. 28, 2, p. 415-423 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4

Bonaccorso, R. L., Chepurny, O. G., Becker-Pauly, C., Holz, G. G. & Doyle, R. P., Sep 8 2015, In : Molecular Pharmaceutics. 12, 9, p. 3502-3506 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ferromagnetic Coupling in "Double-Bridged" Dihydrogenpyrophosphate Complexes of Cobalt(II) and Nickel(II)

Greenfield, T. J., Hoffman, A. E., Marino, N., Goos, A. G., Lloret, F., Julve, M. & Doyle, R. P., Jul 6 2015, In : Inorganic Chemistry. 54, 13, p. 6537-6546 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Vitamin B12 conjugation of peptide-YY3-36 decreases food intake compared to native peptide-YY3-36 upon subcutaneous administration in male rats

Henry, K. E., Elfers, C. T., Burke, R. M., Chepurny, O. G., Holz, G. G., Blevins, J. E., Roth, C. L. & Doyle, R. P., May 1 2015, In : Endocrinology. 156, 5, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Investigation of a vitamin B12 conjugate as a PET imaging probe

Ikotun, O. F., Marquez, B. V., Fazen, C. H., Kahkoska, A. R., Doyle, R. P. & Lapi, S. E., Jun 2014, In : ChemMedChem. 9, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Metal-Citrate Transporter Antigen from Streptomyces Coelicolor and Uses Thereof

Lensbouer, J. J. & Doyle, R., Jul 10 2014, Patent No. 8,992,921

Research output: Patent

Single amino acid chelate complexes of the M(CO)3+ core for correlating fluorescence and radioimaging studies (M = 99mTc or Re)

Coogan, M. P., Doyle, R. P., Valliant, J. F., Babich, J. W. & Zubieta, J., Apr 2014, In : Journal of Labelled Compounds and Radiopharmaceuticals. 57, 4, p. 255-261 7 p.

Research output: Contribution to journalReview article

30 Scopus citations

The antimalarial drug atovaquone binds to saposin B with comparable affinity to coenzyme Q10

Huta, B. P., Roberts, A. M., Waters, E. S., Yu, V. Y., Doyle, R. P., Mehlenbacher, M. R. & Bou-Abdallah, F., Jun 2014, In : MedChemComm. 5, 6, p. 787-791 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Aging-related changes in the iron status of skeletal muscle

DeRuisseau, K. C., Park, Y. M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H. & Doyle, R. P., Nov 1 2013, In : Experimental Gerontology. 48, 11, p. 1294-1302 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Hoffman, A. E., DeStefano, M., Shoen, C., Gopinath, K., Warner, D. F., Cynamon, M. & Doyle, R. P., Jan 1 2013, In : European Journal of Medicinal Chemistry. 70, p. 589-593 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Emission wavelength variation with changes in excitation in a re(-i-)-bisthiazole ligand complex that breaks the kasha-vavilov rule

Henry, K. E., Balasingham, R. G., Vortherms, A. R., Platts, J. A., Valliant, J. F., Coogan, M. P., Zubieta, J. & Doyle, R. P., May 7 2013, In : Chemical Science. 4, 6, p. 2490-2495 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Clardy-James, S., Chepurny, O. G., Leech, C. A., Holz, G. G. & Doyle, R. P., Apr 1 2013, In : ChemMedChem. 8, 4, p. 582-586 5 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Examining the effects of vitamin B12 conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 1 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 1 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Metal-citrate complex uptake and CitMHS transporters: From coordination chemistry to possible vaccine development

Huta, B., Lensboeur, J. J., Lowe, A. J., Zubieta, J. & Doyle, R. P., Dec 1 2012, In : Inorganica Chimica Acta. 393, p. 125-134 10 p.

Research output: Contribution to journalReview article

8 Scopus citations

Pyro without fire: Synthesis, structure, and reactivity of a dimeric vanadyl pyrophosphate coordination complex

Marino, N., Hanson, S. K., Müller, P. & Doyle, R. P., Oct 1 2012, In : Inorganic Chemistry. 51, 19, p. 10077-10079 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Site-selective oxidation of vitamin B12 using 2-iodoxybenzoic acid

Clardy-James, S., Bernstein, J. L., Kerwood, D. J. & Doyle, R. P., Dec 1 2012, In : Synlett. 23, 16, p. 2363-2366 4 p., ST-2012-R0524-L.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis, structural, thermal, and magnetic investigations of Co(II), Ni(II), and Mn(II) pyrophosphate chains

Hoffman, A. E., Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Jul 1 2012, In : Inorganica Chimica Acta. 389, p. 151-158 8 p.

Research output: Contribution to journalArticle

8 Scopus citations