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Research Output 2001 2019

2019

A methylenediphosphonate bridged copper(II) tetramer: Synthesis, structural, thermal, and magnetic characterization of [Cu4(H2O)2(phen)4(μ-P2O6CH2)2]·21H2O

Greenfield, T. J., Takemoto, T., Cano, J., Lloret, F., Julve, M., Zubieta, J. A. & Doyle, R. P., Sep 1 2019, In : Polyhedron. 169, p. 162-168 7 p.

Research output: Contribution to journalArticle

methylene
Copper
copper
synthesis
Organophosphonates
Open Access
Glucagon
Assays
Throughput
Amino Acids
Arginine

Defining the origins of multiple emission/excitation in rhenium-bisthiazole complexes

Azzarelli, N., Ponnala, S., Aguirre, A., Dampf, S. J., Davis, M. P., Ruggiero, M. T., Lopez Diaz, V., Babich, J. W., Coogan, M., Korter, T. M., Doyle, R. P. & Zubieta, J. A., Apr 1 2019, In : Inorganica Chimica Acta. 489, p. 301-309 9 p.

Research output: Contribution to journalArticle

Rhenium
Thiazoles
Putrescine
rhenium
Carbon Monoxide
7 Citations (Scopus)

Exploring the biological, catalytic, and magnetic properties of transition metal coordination complexes incorporating pyrophosphate

Greenfield, T. J., Julve, M. & Doyle, R. P., Apr 1 2019, In : Coordination Chemistry Reviews. 384, p. 37-64 28 p.

Research output: Contribution to journalReview article

Coordination Complexes
Transition metals
Magnetic properties
Negative ions
transition metals
1 Citation (Scopus)

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Chepurny, O. G., Matsoukas, M. T., Liapakis, G., Leech, C. A., Milliken, B. T., Doyle, R. P. & Holz, G. G., Mar 8 2019, In : The Journal of biological chemistry. 294, 10, p. 3514-3531 18 p.

Research output: Contribution to journalArticle

Open Access
Glucagon
Assays
Throughput
Glucagon-Like Peptide 1
G-Protein-Coupled Receptors

Synthesis, structure and magnetic properties of a binuclear Co(II)-pyrophosphate complex, [Co2(phenanthroline-dione)4(P2O7)]

Zito, E., Greenfield, T. J., Minichelli, J., Nanao, M., Turnbull, M. M., Doyle, R. P. & Zubieta, J. A., Sep 15 2019, In : Polyhedron. 170, p. 705-711 7 p.

Research output: Contribution to journalArticle

Phenanthrolines
Dione
Scaffolds
Magnetic properties
Ligands

Systemically Administered Plant Recombinant Holo-Intrinsic Factor Targets the Liver and is not Affected by Endogenous B12 levels

Workinger, J. L., Kuda-Wedagedara, A. N. W., Julin, M. M., White, J. M., Nexo, E., Viola, N. T. & Doyle, R. P., Dec 1 2019, In : Scientific Reports. 9, 1, 12269.

Research output: Contribution to journalArticle

Open Access
Intrinsic Factor
Liver
Stomach
Vitamin B 12
Glycosylation
2018
6 Citations (Scopus)

A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents

Mietlicki-Baase, E. G., Liberini, C. G., Workinger, J. L., Bonaccorso, R. L., Borner, T., Reiner, D. J., Koch-Laskowski, K., Mcgrath, L. E., Lhamo, R., Stein, L. M., De Jonghe, B. C., Holz, G. G., Roth, C. L., Doyle, R. P. & Hayes, M. R., Jan 1 2018, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Vitamin B 12
Nausea
Rodentia
Glucose
Penetrance
2 Citations (Scopus)

Challenges in the diagnosis of magnesium status

Workinger, J. L., Doyle, R. P. & Bortz, J., Sep 1 2018, In : Nutrients. 10, 9, 1202.

Research output: Contribution to journalReview article

Magnesium
magnesium
Magnesium Deficiency
Minerals
Nervous System Diseases
1 Citation (Scopus)

Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Dec 1 2018, In : Scientific Reports. 8, 1, 3749.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Peptides
Appetite
Blood Glucose
Adenosine A2B Receptors

Erratum: Publisher Correction: Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors (Scientific reports (2018) 8 1 (3749))

Chepurny, O. G., Bonaccorso, R. L., Leech, C. A., Wöllert, T., Langford, G. M., Schwede, F., Roth, C. L., Doyle, R. P. & Holz, G. G., Apr 13 2018, In : Scientific reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Peptides
Glucagon-Like Peptide-1 Receptor

Peptide Coagonists of the GLP-1 and NPY-2 Receptors

Doyle, R. & Bonaccorso, R., Oct 30 2018, Patent No. 10,111,932

Research output: Patent

Glucagon-Like Peptide 1
Peptides
Substrates
Glucagon-Like Peptide-1 Receptor
neuropeptide Y2 receptor
1 Citation (Scopus)

Recombinant manganese peroxidase reduces A2E burden in age-related and stargardt's macular degeneration models

Moody, K. J., Tinklepaugh, J., Obert, E., Grohn, K., Derosa, J. R., Lumen, E., Moyer, B. S., Campbell, S., Wolfe, A. J., Sleeper, M. B., Bianchi, A. H., Fisher, C., Applegate, J., Leary, E., Leclair, N., Wortel, D., Doyle, R. P., Rohrer, B. & Blanden, A. R., Dec 1 2018, In : Rejuvenation Research. 21, 6, p. 560-571 12 p.

Research output: Contribution to journalArticle

manganese peroxidase
Macular Degeneration
Enzyme Therapy
Retinoids
Enzyme Replacement Therapy
2017
6 Citations (Scopus)

89Zr-Cobalamin PET Tracer: Synthesis, cellular uptake, and use for tumor imaging

Kuda-Wedagedara, A. N. W., Workinger, J. L., Nexo, E., Doyle, R. P. & Viola-Villegas, N., 2017, In : ACS Omega. 2, 10, p. 6314-6320 7 p.

Research output: Contribution to journalArticle

Vitamin B 12
Tumors
Imaging techniques
Cells
Positron emission tomography
Assays
Saposins
Patents and inventions
Carrier Proteins
Spectroscopy

Compositions and Methods for Enhancing Peptide Stability Against Protease Digestion

Hermelin, D. S., Bortz, J. D. & Doyle, R., Nov 20 2017

Research output: Patent

Peptide Hydrolases
Peptides
Patents and inventions
Chemical analysis
2 Citations (Scopus)

Exploring the multiligand binding specificity of saposin B reveals two binding sites

Tinklepaugh, J., Smith, B. M., Hanlon, E., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., 2017, In : ACS Omega. 2, 10, p. 7141-7145 5 p.

Research output: Contribution to journalArticle

Saposins
Binding sites
Binding Sites
Ligands
Fluorescence spectroscopy
Intrinsic Factor
Glucagon-Like Peptide 1
Vitamin B 12
Blood Glucose
Peptides
3 Citations (Scopus)

Just a Gut Feeling: Central Nervous Effects of Peripheral Gastrointestinal Hormones

Roth, C. L. & Doyle, R. P., 2017, In : Endocrine Development. 32, p. 100-123 24 p.

Research output: Contribution to journalArticle

Gastrointestinal Hormones
Emotions
Appetite Regulation
Obesity
Pediatric Obesity

Metal-citrate complex transport in Kineococcus radiotolerans

Huta, B. P., Miller, N. H., Robertson, E. L. & Doyle, R. P., Jan 1 2017, (Accepted/In press) In : Journal of Basic Microbiology.

Research output: Contribution to journalArticle

Coordination Complexes
Citric Acid
Metals
Calcium Citrate
Ions

Vitamin B12 and drug development

Workinger, J. L. & Doyle, R. P., Jan 1 2017, Vitamin B12: Advances and Insights. CRC Press, p. 338-364 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vitamins
vitamin B12
Vitamin B 12
methylmalonyl-CoA mutase
Methylmalonyl-CoA Mutase
2016
Intrinsic Factor
Vitamin B 12
Transcobalamins
Endocytosis
Neoplasms

Methods and Systems for Zinc Delivery Using Intrinsic Factor or Haptocorrin

Doyle, R., Mar 24 2016, Patent No. 9,505,825

Research output: Patent

Transcobalamins
Intrinsic Factor
Zinc
Phytic Acid
Binding Sites
7 Citations (Scopus)

Solution Structure and Constrained Molecular Dynamics Study of Vitamin B12 Conjugates of the Anorectic Peptide PYY(3-36)

Henry, K. E., Kerwood, D. J., Allis, D. G., Workinger, J. L., Bonaccorso, R. L., Holz, G. G., Roth, C. L., Zubieta, J. A. & Doyle, R. P., 2016, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticle

Appetite Depressants
Molecular Dynamics Simulation
Vitamin B 12
Molecular dynamics
Peptides
6 Citations (Scopus)

The Lysosomal Protein Saposin B Binds Chloroquine

Huta, B. P., Mehlenbacher, M. R., Nie, Y., Lai, X., Zubieta, C., Bou-Abdallah, F. & Doyle, R. P., Feb 4 2016, In : ChemMedChem. 11, 3, p. 277-282 6 p.

Research output: Contribution to journalArticle

Saposins
Chloroquine
Toxicity
Lipids
lysosomal proteins
2015
5 Citations (Scopus)

Clinical isolates of Candida albicans, Candida tropicalis, and Candida krusei have different susceptibilities to Co(II) and Cu(II) complexes of 1,10-phenanthroline

Hoffman, A. E., Miles, L., Greenfield, T. J., Shoen, C., Destefano, M., Cynamon, M. & Doyle, R. P., Apr 1 2015, In : BioMetals. 28, 2, p. 415-423 9 p.

Research output: Contribution to journalArticle

Candida tropicalis
Candida krusei
Candida
Candida albicans
Copper
7 Citations (Scopus)

Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4

Bonaccorso, R. L., Chepurny, O. G., Becker-Pauly, C., Holz, G. G. & Doyle, R. P., Sep 8 2015, In : Molecular Pharmaceutics. 12, 9, p. 3502-3506 5 p.

Research output: Contribution to journalArticle

Intrinsic Factor
Vitamin B 12
Digestion
Peptide Hydrolases
Tiopronin
7 Citations (Scopus)

Ferromagnetic Coupling in "Double-Bridged" Dihydrogenpyrophosphate Complexes of Cobalt(II) and Nickel(II)

Greenfield, T. J., Hoffman, A. E., Marino, N., Goos, A. G., Lloret, F., Julve, M. & Doyle, R. P., Jul 6 2015, In : Inorganic Chemistry. 54, 13, p. 6537-6546 10 p.

Research output: Contribution to journalArticle

Cobalt
Nickel
cobalt
Metals
nickel
15 Citations (Scopus)

Vitamin B12 conjugation of peptide-YY3-36 decreases food intake compared to native peptide-YY3-36 upon subcutaneous administration in male rats

Henry, K. E., Elfers, C. T., Burke, R. M., Chepurny, O. G., Holz, G. G., Blevins, J. E., Roth, C. L. & Doyle, R. P., May 1 2015, In : Endocrinology. 156, 5, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

Vitamin B 12
Eating
tyrosyltyrosine
Therapeutics
Rhombencephalon
2014
9 Citations (Scopus)

Investigation of a vitamin B12 conjugate as a PET imaging probe

Ikotun, O. F., Marquez, B. V., Fazen, C. H., Kahkoska, A. R., Doyle, R. P. & Lapi, S. E., 2014, In : ChemMedChem. 9, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

Positron emission tomography
Vitamin B 12
Positron-Emission Tomography
Imaging techniques
Nutrients

Metal-Citrate Transporter Antigen from Streptomyces Coelicolor and Uses Thereof

Lensbouer, J. J. & Doyle, R., Jul 10 2014, Patent No. 8,992,921

Research output: Patent

Streptomyces coelicolor
Vaccines
Metals
Antigens
Bacteria
26 Citations (Scopus)
Carbon Monoxide
Rhenium
Fluorescence
Amino Acids
Ligands
2 Citations (Scopus)

The antimalarial drug atovaquone binds to saposin B with comparable affinity to coenzyme Q10

Huta, B. P., Roberts, A. M., Waters, E. S., Yu, V. Y., Doyle, R. P., Mehlenbacher, M. R. & Bou-Abdallah, F., 2014, In : MedChemComm. 5, 6, p. 787-791 5 p.

Research output: Contribution to journalArticle

coenzyme Q10
Saposins
Atovaquone
Antimalarials
Cytochromes
2013
13 Citations (Scopus)

Aging-related changes in the iron status of skeletal muscle

Deruisseau, K. C., Park, Y. M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H. & Doyle, R. P., Nov 2013, In : Experimental Gerontology. 48, 11, p. 1294-1302 9 p.

Research output: Contribution to journalArticle

Muscle
Skeletal Muscle
Iron
Aging of materials
Muscles
25 Citations (Scopus)

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Hoffman, A. E., DeStefano, M., Shoen, C., Gopinath, K., Warner, D. F., Cynamon, M. & Doyle, R. P., 2013, In : European Journal of Medicinal Chemistry. 70, p. 589-593 5 p.

Research output: Contribution to journalArticle

Mycobacterium
Tuberculosis
Cobalt
Copper
Metals
21 Citations (Scopus)

Emission wavelength variation with changes in excitation in a Re(i)-bisthiazole ligand complex that breaks the Kasha-Vavilov rule

Henry, K. E., Balasingham, R. G., Vortherms, A. R., Platts, J. A., Valliant, J. F., Coogan, M. P., Zubieta, J. A. & Doyle, R. P., Jun 2013, In : Chemical Science. 4, 6, p. 2490-2495 6 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Rhenium
Ligands
Imaging techniques
Thiazoles
23 Citations (Scopus)

Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Clardy-James, S., Chepurny, O. G., Leech, C. A., Holz, G. G. & Doyle, R. P., Apr 2013, In : ChemMedChem. 8, 4, p. 582-586 5 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Glucagon-Like Peptide 1
Vitamin B 12
Peptides
Weapons
2012
10 Citations (Scopus)

Examining the effects of vitamin B12 conjugation on the biological activity of insulin: A molecular dynamic and in vivo oral uptake investigation

Clardy-James, S., Allis, D. G., Fairchild, T. J. & Doyle, R. P., Sep 2012, In : MedChemComm. 3, 9, p. 1054-1058 5 p.

Research output: Contribution to journalArticle

Molecular Dynamics Simulation
Vitamin B 12
Bioactivity
Molecular dynamics
Insulin
5 Citations (Scopus)

Expression and purification of human PYY(3-36) in Escherichia coli using a His-tagged small ubiquitin-like modifier fusion

Fazen, C. H., Kahkoska, A. R. & Doyle, R. P., Sep 2012, In : Protein Expression and Purification. 85, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Ubiquitin
Peptide Hydrolases
Escherichia coli
Digestion
Factor Xa
8 Citations (Scopus)

Metal-citrate complex uptake and CitMHS transporters: From coordination chemistry to possible vaccine development

Huta, B., Lensboeur, J. J., Lowe, A. J., Zubieta, J. A. & Doyle, R. P., Dec 1 2012, In : Inorganica Chimica Acta. 393, p. 125-134 10 p.

Research output: Contribution to journalArticle

vaccines
transporter
Vaccines
citrates
Citric Acid
9 Citations (Scopus)

Pyro without fire: Synthesis, structure, and reactivity of a dimeric vanadyl pyrophosphate coordination complex

Marino, N., Hanson, S. K., Müller, P. & Doyle, R. P., Oct 1 2012, In : Inorganic Chemistry. 51, 19, p. 10077-10079 3 p.

Research output: Contribution to journalArticle

Benzyl Alcohol
Nanocrystalline powders
Vanadates
Coordination Complexes
catalytic activity
10 Citations (Scopus)

Site-selective oxidation of vitamin B12 using 2-iodoxybenzoic acid

Clardy-James, S., Bernstein, J. L., Kerwood, D. J. & Doyle, R. P., 2012, In : Synlett. 23, 16, p. 2363-2366 4 p., ST-2012-R0524-L.

Research output: Contribution to journalArticle

Vitamin B 12
Nuclear magnetic resonance
Derivatives
Oxidation
Ribose
8 Citations (Scopus)

Synthesis, structural, thermal, and magnetic investigations of Co(II), Ni(II), and Mn(II) pyrophosphate chains

Hoffman, A. E., Marino, N., Lloret, F., Julve, M. & Doyle, R. P., Jul 1 2012, In : Inorganica Chimica Acta. 389, p. 151-158 8 p.

Research output: Contribution to journalArticle

Phenanthrolines
Metals
synthesis
metals
Manganese
1 Citation (Scopus)

Tailoring quantum dot interfaces for improved biofunctionality and energy transfer

Zylstra, J., Alam, R., Han, H., Doyle, R. P. & Maye, M. M., Nov 26 2012, ACS Symposium Series. American Chemical Society, Vol. 1112. p. 59-79 21 p. (ACS Symposium Series; vol. 1112).

Research output: Chapter in Book/Report/Conference proceedingChapter

Histidine
Energy transfer
Semiconductor quantum dots
Surface chemistry
Labeling
2011
43 Citations (Scopus)

A modular phase transfer and ligand exchange protocol for quantum dots

Zylstra, J., Amey, J., Miska, N. J., Pang, L., Hine, C. R., Langer, J., Doyle, R. P. & Maye, M. M., Apr 19 2011, In : Langmuir. 27, 8, p. 4371-4379 9 p.

Research output: Contribution to journalArticle

Semiconductor quantum dots
Ligands
quantum dots
histidine
ligands
28 Citations (Scopus)

A water soluble vitamin B 12-Re(I) fluorescent conjugate for cell uptake screens: Use in the confirmation of cubilin in the lung cancer line A549

Vortherms, A. R., Kahkoska, A. R., Rabideau, A. E., Zubieta, J. A., Andersen, L. L., Madsen, M. & Doyle, R. P., Sep 21 2011, In : Chemical Communications. 47, 35, p. 9792-9794 3 p.

Research output: Contribution to journalArticle

Vitamins
Vitamin B 12
Cells
Rhenium
Intrinsic Factor
47 Citations (Scopus)

Isostructural Pd II and Pt II pyrophosphato complexes: Polymorphism and unusual bond character in d 8-d 8 systems

Marino, N., Fazen, C. H., Blakemore, J. D., Incarvito, C. D., Hazari, N. & Doyle, R. P., Mar 21 2011, In : Inorganic Chemistry. 50, 6, p. 2507-2520 14 p.

Research output: Contribution to journalArticle

polymorphism
Polymorphism
Crystals
crystals
Water

Metal-Citrate Transporter Antigen from Streptomyces Coelicolor and Uses Thereof

Lensbouer, J. J. & Doyle, R., Aug 4 2011, Patent No. 8,673,320

Research output: Patent

Streptomyces coelicolor
Vaccines
Metals
Antigens
Bacteria
Coordination Complexes
Cells
Phenanthrolines
Patents and inventions
diphosphoric acid
25 Citations (Scopus)

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Fazen, C. H., Valentin, D., Fairchild, T. J. & Doyle, R. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8707-8711 5 p.

Research output: Contribution to journalArticle

Appetite Regulation
Appetite
Vitamin B 12
Weight Loss
Peptides