Research Output 1995 2017

  • 2454 Citations
  • 28 h-Index from Scopus
  • 67 Article
  • 2 Chapter
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2017

Aberrantly Large Single-Channel Conductance of Polyhistidine Arm-Containing Protein Nanopores

Thakur, A. K., Larimi, M. G., Gooden, K. & Movileanu, L. Sep 12 2017 In : Biochemistry. 56, 36, p. 4895-4905 11 p.

Research output: Research - peer-reviewArticle

Nanopores
Proteins
polyhistidine
His-His-His-His-His-His
Membrane Proteins
1 Citations

Interrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy

Wolfe, A. J., Hsueh, Y. C., Blanden, A. R., Mohammad, M. M., Pham, B., Thakur, A. K., Loh, S. N., Chen, M. & Movileanu, L. Aug 1 2017 In : Analytical Chemistry. 89, 15, p. 8013-8020 8 p.

Research output: Research - peer-reviewArticle

Nanopores
Detergents
Fluorescence
Spectroscopy
Polarization
2016
6 Citations

Global redesign of a native β-barrel scaffold

Wolfe, A. J., Mohammad, M. M., Thakur, A. K. & Movileanu, L. Jan 1 2016 In : Biochimica et Biophysica Acta - Biomembranes. 1858, 1, p. 19-29A

Research output: Research - peer-reviewArticle

Porins
Scaffolds
Proteins
Surface charge
Peptides
3 Citations

The Transmembrane Domain of a Bicomponent ABC Transporter Exhibits Channel-Forming Activity

Mohammad, M. M., Tomita, N., Ohta, M. & Movileanu, L. Sep 16 2016 In : ACS Chemical Biology. 11, 9, p. 2506-2518 13 p.

Research output: Research - peer-reviewArticle

ATP-Binding Cassette Transporters
Proteins
Carrier Proteins
Nucleotides
Adenosine Triphosphate
9 Citations

Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore

Couoh-Cardel, S., Hsueh, Y. C., Wilkens, S. & Movileanu, L. Apr 21 2016 In : Scientific Reports. 6, 24774

Research output: Research - peer-reviewArticle

Proteolipids
Porins
Adenosine Triphosphatases
Yeasts
Membrane Fusion
2015

Erratum: Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore (Molecular Pharmacology (2015) 87 (825-831))

Blanden, R., Yu, X., Aaron, J. W., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N. Dec 1 2015 In : Molecular Pharmacology. 88, 6, p. 1084 1 p.

Research output: Research - peer-reviewArticle

5 Citations

Quasithermodynamic contributions to the fluctuations of a protein nanopore

Cheneke, B. R., Van Den Berg, B. & Movileanu, L. Mar 20 2015 In : ACS Chemical Biology. 10, 3, p. 784-794 11 p.

Research output: Research - peer-reviewArticle

Nanopores
Proteins
Chemical activation
Enthalpy
Entropy
14 Citations

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore

Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N. May 1 2015 In : Molecular Pharmacology. 87, 5, p. 825-831 7 p.

Research output: Research - peer-reviewArticle

Metallochaperones
Ionophores
Zinc
Neoplasms
Metals
2014
11 Citations

Watching single proteins using engineered nanopores

Movileanu, L. Mar 2014 In : Protein and Peptide Letters. 21, 3, p. 235-246 12 p.

Research output: Research - peer-reviewArticle

Nanopores
Proteins
Molecules
Protein Engineering
Protein Array Analysis
2013
18 Citations

Determination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cells

Singh, D. R., Mohammad, M. M., Patowary, S., Stoneman, M. R., Oliver, J. A., Movileanu, L. & Raicu, V. Feb 2013 In : Integrative Biology (United Kingdom). 5, 2, p. 312-323 12 p.

Research output: Research - peer-reviewArticle

Bacterial Structures
ATP-Binding Cassette Transporters
Cells
Lipopolysaccharides
Pseudomonas aeruginosa
3 Citations

Does the lipid environment impact the open-state conductance of an engineered β-barrel protein nanopore?

Tomita, N., Mohammad, M. M., Niedzwiecki, D. J., Ohta, M. & Movileanu, L. Mar 2013 In : Biochimica et Biophysica Acta - Biomembranes. 1828, 3, p. 1057-1065 9 p.

Research output: Research - peer-reviewArticle

Nanopores
Lipids
Proteins
iron (III) hydroxamate
Lipid Bilayers
8 Citations
Enthalpy
Entropy
Compensation and Redress
Temperature
Protein folding
1 Citations

Erratum: Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore (ACS Nano (2013) 7 DOI: 10.1021/nn400125c)

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L. Apr 23 2013 In : ACS Nano. 7, 4, p. 3731 1 p.

Research output: Research - peer-reviewArticle

32 Citations

Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L. Apr 23 2013 In : ACS Nano. 7, 4, p. 3341-3350 10 p.

Research output: Research - peer-reviewArticle

Nucleocapsid Proteins
Nanopores
Biomarkers
Viruses
Sampling
26 Citations

Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa

Eren, E., Parkin, J., Adelanwa, A., Cheneke, B., Movileanu, L., Khalid, S. & Van Den Berg, B. Apr 26 2013 In : Journal of Biological Chemistry. 288, 17, p. 12042-12053 12 p.

Research output: Research - peer-reviewArticle

Membranes
Molecules
Substrates
Ion Channels
Pseudomonas aeruginosa
2012
14 Citations

An outer membrane protein undergoes enthalpy- and entropy-driven transitions

Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L. Jul 3 2012 In : Biochemistry. 51, 26, p. 5348-5358 11 p.

Research output: Research - peer-reviewArticle

Enthalpy
Membrane Proteins
Entropy
Temperature
Chemical activation
15 Citations

Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa

Liu, J., Wolfe, A. J., Eren, E., Vijayaraghavan, J., Indic, M., Van Den Berg, B. & Movileanu, L. Nov 2012 In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2908-2916 9 p.

Research output: Research - peer-reviewArticle

Ion Channels
Pseudomonas aeruginosa
Cations
Membranes
Proteins
48 Citations

Engineering a rigid protein tunnel for biomolecular detection

Mohammad, M. M., Iyer, R., Howard, K. R., McPike, M. P., Borer, P. N. & Movileanu, L. Jun 6 2012 In : Journal of the American Chemical Society. 134, 22, p. 9521-9531 11 p.

Research output: Research - peer-reviewArticle

Tunnels
Proteins
Nanopores
Membrane Proteins
iron (III) hydroxamate
9 Citations

Inspection of the Engineered FhuA Δc/Δ4L Protein Nanopore by Polymer Exclusion

Niedzwiecki, D. J., Mohammad, M. M. & Movileanu, L. Nov 21 2012 In : Biophysical Journal. 103, 10, p. 2115-2124 10 p.

Research output: Research - peer-reviewArticle

Nanopores
Polymers
Proteins
iron (III) hydroxamate
Ethylene Glycols
20 Citations

OccK channels from pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity

Liu, J., Eren, E., Vijayaraghavan, J., Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L. Mar 20 2012 In : Biochemistry. 51, 11, p. 2319-2330 12 p.

Research output: Research - peer-reviewArticle

Pseudomonas aeruginosa
Anions
Membrane Proteins
Proteins
protein K
47 Citations

Substrate specificity within a family of outer membrane carboxylate channels

Eren, E., Vijayaraghavan, J., Liu, J., Cheneke, B. R., Touw, D. S., Lepore, B. W., Indic, M., Movileanu, L. & van den Berg, B. Jan 2012 In : PLoS biology.. 10, 1, e1001242

Research output: Research - peer-reviewArticle

Substrate Specificity
Ion Channels
Anti-Bacterial Agents
Bacteria
Membranes
2011
19 Citations

Analysis of gating transitions among the three major open states of the OpdK channel

Cheneke, B. R., Van Den Berg, B. & Movileanu, L. Jun 7 2011 In : Biochemistry. 50, 22, p. 4987-4997 11 p.

Research output: Research - peer-reviewArticle

Membrane Proteins
Kinetics
Proteins
Porins
Lipid bilayers

Monitoring protein adsorption with solid-state nanopores

Niedzwiecki, D. J. & Movileanu, L. 2011 In : Journal of Visualized Experiments. 58, e3560

Research output: Research - peer-reviewArticle

Nanopores
Adsorption
Monitoring
Proteins
Nitrides

Monitoring protein adsorption with solid-state nanopores.

Niedzwiecki, D. J. & Movileanu, L. 2011 In : Journal of Visualized Experiments. 58

Research output: Research - peer-reviewArticle

Nanopores
Adsorption
Monitoring
Proteins
Nitrides
30 Citations

Redesign of a plugged β-barrel membrane protein

Mohammad, M. M., Howard, K. R. & Movileanu, L. Mar 11 2011 In : Journal of Biological Chemistry. 286, 10, p. 8000-8013 14 p.

Research output: Research - peer-reviewArticle

Membrane Proteins
Proteins
iron (III) hydroxamate
Protein Engineering
Bacterial Outer Membrane Proteins
2010
28 Citations

Facilitated translocation of polypeptides through a single nanopore

Bikwemu, R., Wolfe, A. J., Xing, X. & Movileanu, L. Nov 17 2010 In : Journal of Physics Condensed Matter. 22, 45, 454117

Research output: Research - peer-reviewArticle

Nanopores
Peptides
Polypeptides
polypeptides
Kinetics
26 Citations

Impact of distant charge reversals within a robust β-barrel protein pore

Mohammad, M. M. & Movileanu, L. Jul 8 2010 In : Journal of Physical Chemistry B. 114, 26, p. 8750-8759 10 p.

Research output: Research - peer-reviewArticle

Protein Engineering
Porins
Hemolysin Proteins
Lipid Bilayers
Aspartic Acid
69 Citations

Single-molecule observation of protein adsorption onto an inorganic surface

Niedzwiecki, D. J., Grazul, J. & Movileanu, L. Aug 11 2010 In : Journal of the American Chemical Society. 132, 31, p. 10816-10822 7 p.

Research output: Research - peer-reviewArticle

Nanopores
Adsorption
Observation
Proteins
Molecules
2009
114 Citations

Interrogating single proteins through nanopores: challenges and opportunities

Movileanu, L. Jun 2009 In : Trends in Biotechnology. 27, 6, p. 333-341 9 p.

Research output: Research - peer-reviewArticle

Nanopores
Proteins
Medical nanotechnology
Porins
Mechanical stability
2008
75 Citations

Controlling a single protein in a nanopore through electrostatic traps

Mohammad, M. M., Prakash, S., Matouschek, A. & Movileanu, L. Mar 26 2008 In : Journal of the American Chemical Society. 130, 12, p. 4081-4088 8 p.

Research output: Research - peer-reviewArticle

Nanopores
Static Electricity
Proteins
Electrostatics
Porins
33 Citations

Crystal Structure of the Outer Membrane Protein OpdK from Pseudomonas aeruginosa

Biswas, S., Mohammad, M. M., Movileanu, L. & van den Berg, B. Jul 9 2008 In : Structure. 16, 7, p. 1027-1035 9 p.

Research output: Research - peer-reviewArticle

Pseudomonas aeruginosa
Membrane Proteins
Porins
Substrate Specificity
Gram-Negative Bacteria
52 Citations

Excursion of a single polypeptide into a protein pore: Simple physics, but complicated biology

Mohammad, M. M. & Movileanu, L. Jul 2008 In : European Biophysics Journal. 37, 6, p. 913-925 13 p.

Research output: Research - peer-reviewArticle

Porins
Physics
Peptides
Proteins
Static Electricity
58 Citations

Squeezing a single polypeptide through a nanopore

Movileanu, L. 2008 In : Soft Matter. 4, 5, p. 925-931 7 p.

Research output: Research - peer-reviewArticle

polypeptides
compressing
proteins
Nanopores
Peptides
47 Citations

Transport at the nanoscale: Temperature dependence of ion conductance

Chimerel, C., Movileanu, L., Pezeshki, S., Winterhalter, M. & Kleinekathöfer, U. Nov 2008 In : European Biophysics Journal. 38, 1, p. 121-125 5 p.

Research output: Research - peer-reviewArticle

Nanopores
Ions
Temperature
Ion Transport
Salts
2007
96 Citations

Catalyzing the translocation of polypeptides through attractive interactions

Wolfe, A. J., Mohammad, M. M., Cheley, S., Bayley, H. & Movileanu, L. Nov 14 2007 In : Journal of the American Chemical Society. 129, 45, p. 14034-14041 8 p.

Research output: Research - peer-reviewArticle

Peptides
Polypeptides
Binding Sites
Binding sites
Proteins
64 Citations

Single-molecule electrophoresis of β-hairpin peptides by electrical recordings and Langevin dynamics simulations

Goodrich, C. P., Kirmizialtin, S., Huyghues-Despointes, B. M., Zhu, A., Scholtz, J. M., Makarov, D. E. & Movileanu, L. Apr 5 2007 In : Journal of Physical Chemistry B. 111, 13, p. 3332-3335 4 p.

Research output: Research - peer-reviewArticle

electrophoresis
peptides
recording
molecules
simulation
60 Citations

Structural insight into OprD substrate specificity

Biswas, S., Mohammad, M. M., Patel, D. R., Movileanu, L. & Van Den Berg, B. Nov 2007 In : Nature Structural and Molecular Biology. 14, 11, p. 1108-1109 2 p.

Research output: Research - peer-reviewArticle

Substrate Specificity
Gram-Negative Bacteria
Ion Channels
Constriction
Pseudomonas aeruginosa
2006
87 Citations

Temperature-responsive protein pores

Jung, Y., Bayley, H. & Movileanu, L. Nov 29 2006 In : Journal of the American Chemical Society. 128, 47, p. 15332-15340 9 p.

Research output: Research - peer-reviewArticle

Porins
Elastin
Peptides
Temperature
Polypeptides
13 Citations

Transbilayer pores induced by thickness fluctuations

Movileanu, L., Popescu, D., Ion, S. & Popescu, A. I. Aug 2006 In : Bulletin of Mathematical Biology. 68, 6, p. 1231-1255 25 p.

Research output: Research - peer-reviewArticle

Phospholipids
Fluctuations
phospholipid
phospholipids
Unstable
2005
33 Citations

Ethanol-induced alterations of the antioxidant defense system in rat kidney

Dinu, D., Nechifor, M. T. & Movileanu, L. 2005 In : Journal of Biochemical and Molecular Toxicology. 19, 6, p. 386-395 10 p.

Research output: Research - peer-reviewArticle

Ethanol
Antioxidants
Kidney
Rats
Glutathione Reductase
165 Citations

Interactions of peptides with a protein pore

Movileanu, L., Schmittschmitt, J. P., Scholtz, J. M. & Bayley, H. Aug 2005 In : Biophysical Journal. 89, 2, p. 1030-1045 16 p.

Research output: Research - peer-reviewArticle

Porins
Peptides
Hemolysin Proteins
Membrane Potentials
Nuclear Pore Complex Proteins
2003
3 Citations

Chapter 5 Elastic properties of bilayer lipid membranes and pore formation

Popescu, D., Ion, S., Popescu, A. & Movileanu, L. 2003 In : Membrane Science and Technology. 7, C, p. 173-204 32 p.

Research output: Research - peer-reviewArticle

74 Citations

Partitioning of individual flexible polymers into a nanoscopic protein pore

Movileanu, L., Cheley, S. & Bayley, H. Aug 1 2003 In : Biophysical Journal. 85, 2, p. 897-910 14 p.

Research output: Research - peer-reviewArticle

Porins
Polymers
Hemolysin Proteins
Ethylene Glycol
Biotechnology
2002
5 Citations

Comparative study of some energetic and steric parameters of the wild type and mutants HIV-1 protease: A way to explain the viral resistance

Avram, S., Movileanu, L., Mihailescu, D. & Flonta, M. L. Apr 2002 In : Journal of Cellular and Molecular Medicine. 6, 2, p. 251-260 10 p.

Research output: Research - peer-reviewArticle

HIV-1
Human immunodeficiency virus 1 p16 protease
Static Electricity
Mutation
Electrostatics
32 Citations

Determination of base and backbone contributions to the thermodynamics of premelting and melting transitions in B DNA

Movileanu, L., Benevides, J. M. & Thomas, G. J. Sep 1 2002 In : Nucleic Acids Research. 30, 17, p. 3767-3777 11 p.

Research output: Research - peer-reviewArticle

Thermodynamics
Freezing
DNA
polydeoxyadenylic acid-polythymidylic acid
Poly dA-dT
86 Citations

Subunit composition of a bicomponent toxin: Staphylococcal leukocidin forms an octameric transmembrane pore

Miles, G., Movileanu, L. & Bayley, H. 2002 In : Protein Science. 11, 4, p. 894-902 9 p.

Research output: Research - peer-reviewArticle

Leukocidins
Chemical analysis
Hemolysin Proteins
Chemical modification
Electrophoresis
68 Citations
Poly dA-dT
Raman scattering
Melting
DNA
Temperature
2001
140 Citations

Kinetics of duplex formation for individual DNA strands within a single protein nanopore

Howorka, S., Movileanu, L., Braha, O. & Bayley, H. Nov 6 2001 In : Proceedings of the National Academy of Sciences of the United States of America. 98, 23, p. 12996-13001 6 p.

Research output: Research - peer-reviewArticle

Nanopores
DNA
Proteins
Oligonucleotides
Porins
56 Citations

Location of a constriction in the lumen of a transmembrane pore by targeted covalent attachment of polymer molecules

Movileanu, L., Cheley, S., Howorka, S., Braha, O. & Bayley, H. 2001 In : Journal of General Physiology. 117, 3, p. 239-251 13 p.

Research output: Research - peer-reviewArticle

Constriction
Polymers
Cysteine
Crystallography
Lipid Bilayers
75 Citations
Porins
Polymers
Ethylene Glycol
Cysteine
Proteins