• 2865 Citations
  • 31 h-Index
1995 …2023
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Research Output 1995 2019

  • 2865 Citations
  • 31 h-Index
  • 72 Article
  • 2 Chapter
  • 1 Letter
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Article
2019

High-Throughput Screening of Protein-Detergent Complexes Using Fluorescence Polarization Spectroscopy

Wolfe, A. J., Parella, K. J. & Movileanu, L., Sep 1 2019, In : Current protocols in protein science. 97, 1, p. e96

Research output: Contribution to journalArticle

Fluorescence Polarization
Fluorescence Spectrometry
Detergents
Screening
Fluorescence
2 Citations (Scopus)

Interactions of a Polypeptide with a Protein Nanopore under Crowding Conditions

Larimi, M. G., Mayse, L. A. & Movileanu, L., Apr 23 2019, In : ACS Nano. 13, 4, p. 4469-4477 9 p.

Research output: Contribution to journalArticle

crowding
Nanopores
Polypeptides
polypeptides
Rate constants

Single-Molecule Protein Detection in a Biofluid Using a Quantitative Nanopore Sensor

Thakur, A. K. & Movileanu, L., Jan 1 2019, (Accepted/In press) In : ACS Sensors.

Research output: Contribution to journalArticle

Nanopores
proteins
Proteins
Molecules
sensors
2018
1 Citation (Scopus)

Detergent Desorption of Membrane Proteins Exhibits Two Kinetic Phases

Wolfe, A. J., Gugel, J. F., Chen, M. & Movileanu, L., Apr 19 2018, In : Journal of Physical Chemistry Letters. 9, 8, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

detergents
Detergents
Desorption
Membrane Proteins
desorption

Kinetics of Membrane Protein-Detergent Interactions Depend on Protein Electrostatics

Wolfe, A. J., Gugel, J. F., Chen, M. & Movileanu, L., Oct 18 2018, In : Journal of Physical Chemistry B. 122, 41, p. 9471-9481 11 p.

Research output: Contribution to journalArticle

detergents
Detergents
Electrostatics
Membrane Proteins
electrostatics
2017
8 Citations (Scopus)

Aberrantly Large Single-Channel Conductance of Polyhistidine Arm-Containing Protein Nanopores

Thakur, A. K., Larimi, M. G., Gooden, K. & Movileanu, L., Sep 12 2017, In : Biochemistry. 56, 36, p. 4895-4905 11 p.

Research output: Contribution to journalArticle

Nanopores
His-His-His-His-His-His
Proteins
Membrane Proteins
Electrophysiology
6 Citations (Scopus)

Interrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy

Wolfe, A. J., Hsueh, Y. C., Blanden, A. R., Mohammad, M. M., Pham, B., Thakur, A. K., Loh, S. N., Chen, M. & Movileanu, L., Aug 1 2017, In : Analytical Chemistry. 89, 15, p. 8013-8020 8 p.

Research output: Contribution to journalArticle

Nanopores
Detergents
Fluorescence
Spectroscopy
Polarization
8 Citations (Scopus)

Quantification of Membrane Protein-Detergent Complex Interactions

Wolfe, A. J., Si, W., Zhang, Z., Blanden, A. R., Hsueh, Y. C., Gugel, J. F., Pham, B., Chen, M., Loh, S. N., Rozovsky, S., Aksimentiev, A. & Movileanu, L., Nov 9 2017, In : Journal of Physical Chemistry B. 121, 44, p. 10228-10241 14 p.

Research output: Contribution to journalArticle

detergents
Detergents
Membrane Proteins
membranes
proteins
2016
11 Citations (Scopus)

Global redesign of a native β-barrel scaffold

Wolfe, A. J., Mohammad, M. M., Thakur, A. K. & Movileanu, L., Jan 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 1, p. 19-29A

Research output: Contribution to journalArticle

Porins
Scaffolds
Surface charge
Electrophysiology
Peptides
3 Citations (Scopus)

The Transmembrane Domain of a Bicomponent ABC Transporter Exhibits Channel-Forming Activity

Mohammad, M. M., Tomita, N., Ohta, M. & Movileanu, L., Sep 16 2016, In : ACS Chemical Biology. 11, 9, p. 2506-2518 13 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Carrier Proteins
Proteins
Nucleotides
Adenosine Triphosphate
16 Citations (Scopus)

Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore

Couoh-Cardel, S., Hsueh, Y. C., Wilkens, S. & Movileanu, L., Apr 21 2016, In : Scientific Reports. 6, 24774.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Proteolipids
Porins
Membrane Fusion
Electrophysiology
2015

Erratum: Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore (Molecular Pharmacology (2015) 87 (825-831))

Blanden, R., Yu, X., Aaron, J. W., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., Dec 1 2015, In : Molecular Pharmacology. 88, 6, p. 1084 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Quasithermodynamic contributions to the fluctuations of a protein nanopore

Cheneke, B. R., Van Den Berg, B. & Movileanu, L., Mar 20 2015, In : ACS Chemical Biology. 10, 3, p. 784-794 11 p.

Research output: Contribution to journalArticle

Nanopores
Chemical activation
Entropy
Enthalpy
Proteins
31 Citations (Scopus)

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore

Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., May 1 2015, In : Molecular Pharmacology. 87, 5, p. 825-831 7 p.

Research output: Contribution to journalArticle

Metallochaperones
Ionophores
Zinc
Neoplasms
Metals
2014
12 Citations (Scopus)

Watching single proteins using engineered nanopores

Movileanu, L., Mar 2014, In : Protein and Peptide Letters. 21, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

Nanopores
Proteins
Protein Engineering
Protein Array Analysis
Molecular Pathology
2013
23 Citations (Scopus)

Determination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cells

Singh, D. R., Mohammad, M. M., Patowary, S., Stoneman, M. R., Oliver, J. A., Movileanu, L. & Raicu, V., Feb 2013, In : Integrative Biology (United Kingdom). 5, 2, p. 312-323 12 p.

Research output: Contribution to journalArticle

Bacterial Structures
ATP-Binding Cassette Transporters
Cells
Lipopolysaccharides
Pseudomonas aeruginosa
6 Citations (Scopus)

Does the lipid environment impact the open-state conductance of an engineered β-barrel protein nanopore?

Tomita, N., Mohammad, M. M., Niedzwiecki, D. J., Ohta, M. & Movileanu, L., Mar 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 3, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

Nanopores
Lipids
Protein C
Proteins
Lipid bilayers
10 Citations (Scopus)

Entropy-enthalpy compensation of biomolecular systems in aqueous phase: A dry perspective

Movileanu, L. & Schiff, E. A., Jan 2013, In : Monatshefte fur Chemie. 144, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Enthalpy
Entropy
Protein folding
Gibbs free energy
Macromolecules
1 Citation (Scopus)

Erratum: Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore (ACS Nano (2013) 7 DOI: 10.1021/nn400125c)

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L., Apr 23 2013, In : ACS Nano. 7, 4, p. 3731 1 p.

Research output: Contribution to journalArticle

Nanopores
Biomarkers
Viruses
Sampling
39 Citations (Scopus)

Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L., Apr 23 2013, In : ACS Nano. 7, 4, p. 3341-3350 10 p.

Research output: Contribution to journalArticle

Nucleocapsid Proteins
human immunodeficiency virus
Nanopores
biomarkers
Biomarkers
38 Citations (Scopus)

Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa

Eren, E., Parkin, J., Adelanwa, A., Cheneke, B., Movileanu, L., Khalid, S. & Van Den Berg, B., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12042-12053 12 p.

Research output: Contribution to journalArticle

Ion Channels
Pseudomonas aeruginosa
Ladders
Membranes
Molecules
2012
17 Citations (Scopus)

An outer membrane protein undergoes enthalpy- and entropy-driven transitions

Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L., Jul 3 2012, In : Biochemistry. 51, 26, p. 5348-5358 11 p.

Research output: Contribution to journalArticle

Entropy
Enthalpy
Membrane Proteins
Temperature
Chemical activation
21 Citations (Scopus)

Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa

Liu, J., Wolfe, A. J., Eren, E., Vijayaraghavan, J., Indic, M., Van Den Berg, B. & Movileanu, L., Nov 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2908-2916 9 p.

Research output: Contribution to journalArticle

Ion Channels
Pseudomonas aeruginosa
Cations
Membranes
Proteins
74 Citations (Scopus)

Engineering a rigid protein tunnel for biomolecular detection

Mohammad, M. M., Iyer, R., Howard, K. R., McPike, M. P., Borer, P. N. & Movileanu, L., Jun 6 2012, In : Journal of the American Chemical Society. 134, 22, p. 9521-9531 11 p.

Research output: Contribution to journalArticle

Tunnels
Nanopores
Proteins
Membrane Proteins
Nucleotide Aptamers
15 Citations (Scopus)

Inspection of the Engineered FhuA Δc/Δ4L Protein Nanopore by Polymer Exclusion

Niedzwiecki, D. J., Mohammad, M. M. & Movileanu, L., Nov 21 2012, In : Biophysical Journal. 103, 10, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Nanopores
Polymers
Ethylene Glycols
Protein Engineering
Proteins
27 Citations (Scopus)

OccK channels from pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity

Liu, J., Eren, E., Vijayaraghavan, J., Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L., Mar 20 2012, In : Biochemistry. 51, 11, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Anions
Membrane Proteins
Conformations
Substrates
66 Citations (Scopus)

Substrate specificity within a family of outer membrane carboxylate channels

Eren, E., Vijayaraghavan, J., Liu, J., Cheneke, B. R., Touw, D. S., Lepore, B. W., Indic, M., Movileanu, L. & van den Berg, B., Jan 2012, In : PLoS biology.. 10, 1, e1001242.

Research output: Contribution to journalArticle

substrate specificity
Substrate Specificity
Ion Channels
Bacteria
antibiotics
2011
23 Citations (Scopus)

Analysis of gating transitions among the three major open states of the OpdK channel

Cheneke, B. R., Van Den Berg, B. & Movileanu, L., Jun 7 2011, In : Biochemistry. 50, 22, p. 4987-4997 11 p.

Research output: Contribution to journalArticle

Membrane Proteins
Porins
Lipid bilayers
Kinetics
Lipid Bilayers

Monitoring protein adsorption with solid-state nanopores

Niedzwiecki, D. J. & Movileanu, L., 2011, In : Journal of Visualized Experiments. 58, e3560.

Research output: Contribution to journalArticle

Nanopores
Adsorption
Proteins
Monitoring
Lab-On-A-Chip Devices
40 Citations (Scopus)

Redesign of a plugged β-barrel membrane protein

Mohammad, M. M., Howard, K. R. & Movileanu, L., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8000-8013 14 p.

Research output: Contribution to journalArticle

Membrane Proteins
Protein Engineering
Proteins
Bacterial Outer Membrane Proteins
Nanopores
2010
36 Citations (Scopus)

Facilitated translocation of polypeptides through a single nanopore

Bikwemu, R., Wolfe, A. J., Xing, X. & Movileanu, L., Nov 17 2010, In : Journal of Physics Condensed Matter. 22, 45, 454117.

Research output: Contribution to journalArticle

Nanopores
Polypeptides
polypeptides
Peptides
traps
29 Citations (Scopus)

Impact of distant charge reversals within a robust β-barrel protein pore

Mohammad, M. M. & Movileanu, L., Jul 8 2010, In : Journal of Physical Chemistry B. 114, 26, p. 8750-8759 10 p.

Research output: Contribution to journalArticle

Protein Engineering
Porins
Hemolysin Proteins
Lipid Bilayers
Aspartic Acid
81 Citations (Scopus)

Single-molecule observation of protein adsorption onto an inorganic surface

Niedzwiecki, D. J., Grazul, J. & Movileanu, L., Aug 11 2010, In : Journal of the American Chemical Society. 132, 31, p. 10816-10822 7 p.

Research output: Contribution to journalArticle

Nanopores
Adsorption
Observation
Proteins
Molecules
2009
129 Citations (Scopus)

Interrogating single proteins through nanopores: challenges and opportunities

Movileanu, L., Jun 2009, In : Trends in Biotechnology. 27, 6, p. 333-341 9 p.

Research output: Contribution to journalArticle

Nanopores
Proteins
Nanomedicine
Medical nanotechnology
Porins
2008
87 Citations (Scopus)

Controlling a single protein in a nanopore through electrostatic traps

Mohammad, M. M., Prakash, S., Matouschek, A. & Movileanu, L., Mar 26 2008, In : Journal of the American Chemical Society. 130, 12, p. 4081-4088 8 p.

Research output: Contribution to journalArticle

Nanopores
Static Electricity
Electrostatics
Porins
Proteins
37 Citations (Scopus)

Crystal Structure of the Outer Membrane Protein OpdK from Pseudomonas aeruginosa

Biswas, S., Mohammad, M. M., Movileanu, L. & van den Berg, B., Jul 9 2008, In : Structure. 16, 7, p. 1027-1035 9 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Membrane Proteins
Porins
Substrate Specificity
Gram-Negative Bacteria
55 Citations (Scopus)

Excursion of a single polypeptide into a protein pore: Simple physics, but complicated biology

Mohammad, M. M. & Movileanu, L., Jul 2008, In : European Biophysics Journal. 37, 6, p. 913-925 13 p.

Research output: Contribution to journalArticle

Porins
Physics
Peptides
Cytochromes b
Static Electricity
67 Citations (Scopus)

Squeezing a single polypeptide through a nanopore

Movileanu, L., 2008, In : Soft Matter. 4, 5, p. 925-931 7 p.

Research output: Contribution to journalArticle

Nanopores
polypeptides
compressing
proteins
Peptides
55 Citations (Scopus)

Transport at the nanoscale: Temperature dependence of ion conductance

Chimerel, C., Movileanu, L., Pezeshki, S., Winterhalter, M. & Kleinekathöfer, U., Nov 2008, In : European Biophysics Journal. 38, 1, p. 121-125 5 p.

Research output: Contribution to journalArticle

Nanopores
Ion Transport
Ions
Temperature
Salts
2007
110 Citations (Scopus)

Catalyzing the translocation of polypeptides through attractive interactions

Wolfe, A. J., Mohammad, M. M., Cheley, S., Bayley, H. & Movileanu, L., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 14034-14041 8 p.

Research output: Contribution to journalArticle

Polypeptides
Binding sites
Peptides
Binding Sites
Proteins
72 Citations (Scopus)

Single-molecule electrophoresis of β-hairpin peptides by electrical recordings and Langevin dynamics simulations

Goodrich, C. P., Kirmizialtin, S., Huyghues-Despointes, B. M., Zhu, A., Scholtz, J. M., Makarov, D. E. & Movileanu, L., Apr 5 2007, In : Journal of Physical Chemistry B. 111, 13, p. 3332-3335 4 p.

Research output: Contribution to journalArticle

electrophoresis
Electrophoresis
Peptides
peptides
recording
67 Citations (Scopus)

Structural insight into OprD substrate specificity

Biswas, S., Mohammad, M. M., Patel, D. R., Movileanu, L. & Van Den Berg, B., Nov 2007, In : Nature Structural and Molecular Biology. 14, 11, p. 1108-1109 2 p.

Research output: Contribution to journalArticle

Substrate Specificity
Gram-Negative Bacteria
Ion Channels
Constriction
Pseudomonas aeruginosa
2006
93 Citations (Scopus)

Temperature-responsive protein pores

Jung, Y., Bayley, H. & Movileanu, L., Nov 29 2006, In : Journal of the American Chemical Society. 128, 47, p. 15332-15340 9 p.

Research output: Contribution to journalArticle

Elastin
Porins
Polypeptides
Proteins
Peptides
15 Citations (Scopus)

Transbilayer pores induced by thickness fluctuations

Movileanu, L., Popescu, D., Ion, S. & Popescu, A. I., Aug 2006, In : Bulletin of Mathematical Biology. 68, 6, p. 1231-1255 25 p.

Research output: Contribution to journalArticle

Phospholipids
phospholipid
phospholipids
Fluctuations
Unstable
2005
42 Citations (Scopus)

Ethanol-induced alterations of the antioxidant defense system in rat kidney

Dinu, D., Nechifor, M. T. & Movileanu, L., 2005, In : Journal of Biochemical and Molecular Toxicology. 19, 6, p. 386-395 10 p.

Research output: Contribution to journalArticle

Rats
Ethanol
Antioxidants
Kidney
Glutathione Reductase
189 Citations (Scopus)

Interactions of peptides with a protein pore

Movileanu, L., Schmittschmitt, J. P., Scholtz, J. M. & Bayley, H., Aug 2005, In : Biophysical Journal. 89, 2, p. 1030-1045 16 p.

Research output: Contribution to journalArticle

Porins
Peptides
Hemolysin Proteins
Membrane Potentials
Nuclear Pore Complex Proteins
2003
4 Citations (Scopus)

Chapter 5 Elastic properties of bilayer lipid membranes and pore formation

Popescu, D., Ion, S., Popescu, A. & Movileanu, L., 2003, In : Membrane Science and Technology. 7, C, p. 173-204 32 p.

Research output: Contribution to journalArticle

Lipid bilayers
Membrane Lipids
83 Citations (Scopus)

Partitioning of individual flexible polymers into a nanoscopic protein pore

Movileanu, L., Cheley, S. & Bayley, H., Aug 1 2003, In : Biophysical Journal. 85, 2, p. 897-910 14 p.

Research output: Contribution to journalArticle

Porins
Polymers
Hemolysin Proteins
Ethylene Glycol
Biotechnology
2002
5 Citations (Scopus)

Comparative study of some energetic and steric parameters of the wild type and mutants HIV-1 protease: A way to explain the viral resistance

Avram, S., Movileanu, L., Mihailescu, D. & Flonta, M. L., Apr 2002, In : Journal of Cellular and Molecular Medicine. 6, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

HIV-1
Static Electricity
Electrostatics
Mutation
Information Storage and Retrieval
33 Citations (Scopus)

Determination of base and backbone contributions to the thermodynamics of premelting and melting transitions in B DNA

Movileanu, L., Benevides, J. M. & Thomas, G. J., Sep 1 2002, In : Nucleic Acids Research. 30, 17, p. 3767-3777 11 p.

Research output: Contribution to journalArticle

Thermodynamics
Poly dA-dT
Freezing
DNA
Base Pairing