• 2688 Citations
  • 30 h-Index
1995 …2022
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Research Output 1995 2018

  • 2688 Citations
  • 30 h-Index
  • 69 Article
  • 2 Chapter
2018
1 Citations

Detergent Desorption of Membrane Proteins Exhibits Two Kinetic Phases

Wolfe, A. J., Gugel, J. F., Chen, M. & Movileanu, L., Apr 19 2018, In : Journal of Physical Chemistry Letters. 9, 8, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

detergents
Detergents
Desorption
Membrane Proteins
desorption

Kinetics of Membrane Protein-Detergent Interactions Depend on Protein Electrostatics

Wolfe, A. J., Gugel, J. F., Chen, M. & Movileanu, L., Oct 18 2018, In : Journal of Physical Chemistry B. 122, 41, p. 9471-9481 11 p.

Research output: Contribution to journalArticle

detergents
Detergents
Electrostatics
Membrane Proteins
electrostatics
2017
5 Citations

Aberrantly Large Single-Channel Conductance of Polyhistidine Arm-Containing Protein Nanopores

Thakur, A. K., Larimi, M. G., Gooden, K. & Movileanu, L., Sep 12 2017, In : Biochemistry. 56, 36, p. 4895-4905 11 p.

Research output: Contribution to journalArticle

Nanopores
His-His-His-His-His-His
Proteins
Membrane Proteins
Electrophysiology
4 Citations

Interrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy

Wolfe, A. J., Hsueh, Y. C., Blanden, A. R., Mohammad, M. M., Pham, B., Thakur, A. K., Loh, S. N., Chen, M. & Movileanu, L., Aug 1 2017, In : Analytical Chemistry. 89, 15, p. 8013-8020 8 p.

Research output: Contribution to journalArticle

Nanopores
Detergents
Fluorescence
Spectroscopy
Polarization
2 Citations

Quantification of Membrane Protein-Detergent Complex Interactions

Wolfe, A. J., Si, W., Zhang, Z., Blanden, A. R., Hsueh, Y. C., Gugel, J. F., Pham, B., Chen, M., Loh, S. N., Rozovsky, S., Aksimentiev, A. & Movileanu, L., Nov 9 2017, In : Journal of Physical Chemistry B. 121, 44, p. 10228-10241 14 p.

Research output: Contribution to journalArticle

detergents
Detergents
Membrane Proteins
membranes
proteins
2016
9 Citations

Global redesign of a native β-barrel scaffold

Wolfe, A. J., Mohammad, M. M., Thakur, A. K. & Movileanu, L., Jan 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 1, p. 19-29A

Research output: Contribution to journalArticle

Porins
Scaffolds
Surface charge
Electrophysiology
Peptides
3 Citations

The Transmembrane Domain of a Bicomponent ABC Transporter Exhibits Channel-Forming Activity

Mohammad, M. M., Tomita, N., Ohta, M. & Movileanu, L., Sep 16 2016, In : ACS Chemical Biology. 11, 9, p. 2506-2518 13 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Carrier Proteins
Proteins
Nucleotides
Adenosine Triphosphate
11 Citations

Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore

Couoh-Cardel, S., Hsueh, Y. C., Wilkens, S. & Movileanu, L., Apr 21 2016, In : Scientific Reports. 6, 24774.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Proteolipids
Porins
Membrane Fusion
Electrophysiology
2015

Erratum: Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore (Molecular Pharmacology (2015) 87 (825-831))

Blanden, R., Yu, X., Aaron, J. W., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., Dec 1 2015, In : Molecular Pharmacology. 88, 6, p. 1084 1 p.

Research output: Contribution to journalArticle

7 Citations

Quasithermodynamic contributions to the fluctuations of a protein nanopore

Cheneke, B. R., Van Den Berg, B. & Movileanu, L., Mar 20 2015, In : ACS Chemical Biology. 10, 3, p. 784-794 11 p.

Research output: Contribution to journalArticle

Nanopores
Chemical activation
Entropy
Enthalpy
Proteins
26 Citations

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore

Blanden, A. R., Yu, X., Wolfe, A. J., Gilleran, J. A., Augeri, D. J., O'Dell, R. S., Olson, E. C., Kimball, S. D., Emge, T. J., Movileanu, L., Carpizo, D. R. & Loh, S. N., May 1 2015, In : Molecular Pharmacology. 87, 5, p. 825-831 7 p.

Research output: Contribution to journalArticle

Metallochaperones
Ionophores
Zinc
Neoplasms
Metals
2014
11 Citations

Watching single proteins using engineered nanopores

Movileanu, L., Mar 2014, In : Protein and Peptide Letters. 21, 3, p. 235-246 12 p.

Research output: Contribution to journalArticle

Nanopores
Proteins
Protein Engineering
Protein Array Analysis
Molecular Pathology
2013
21 Citations

Determination of the quaternary structure of a bacterial ATP-binding cassette (ABC) transporter in living cells

Singh, D. R., Mohammad, M. M., Patowary, S., Stoneman, M. R., Oliver, J. A., Movileanu, L. & Raicu, V., Feb 2013, In : Integrative Biology (United Kingdom). 5, 2, p. 312-323 12 p.

Research output: Contribution to journalArticle

Bacterial Structures
ATP-Binding Cassette Transporters
Cells
Lipopolysaccharides
Pseudomonas aeruginosa
6 Citations

Does the lipid environment impact the open-state conductance of an engineered β-barrel protein nanopore?

Tomita, N., Mohammad, M. M., Niedzwiecki, D. J., Ohta, M. & Movileanu, L., Mar 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 3, p. 1057-1065 9 p.

Research output: Contribution to journalArticle

Nanopores
Lipids
Proteins
Lipid bilayers
Lipid Bilayers
10 Citations

Entropy-enthalpy compensation of biomolecular systems in aqueous phase: A dry perspective

Movileanu, L. & Schiff, E. A., Jan 2013, In : Monatshefte fur Chemie. 144, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

Enthalpy
Entropy
Protein folding
Gibbs free energy
Macromolecules
1 Citations

Erratum: Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore (ACS Nano (2013) 7 DOI: 10.1021/nn400125c)

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L., Apr 23 2013, In : ACS Nano. 7, 4, p. 3731 1 p.

Research output: Contribution to journalArticle

human immunodeficiency virus
Nanopores
biomarkers
Biomarkers
Viruses
33 Citations

Sampling a biomarker of the human immunodeficiency virus across a synthetic nanopore

Niedzwiecki, D. J., Iyer, R., Borer, P. N. & Movileanu, L., Apr 23 2013, In : ACS Nano. 7, 4, p. 3341-3350 10 p.

Research output: Contribution to journalArticle

Nucleocapsid Proteins
human immunodeficiency virus
Nanopores
biomarkers
Biomarkers
4 Citations

Single-molecule detection of proteins using nanopores

Movileanu, L., Nov 1 2013, Frontiers in Sensing: From Biology to Engineering. Springer-Verlag Wien, p. 363-381 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanopores
Proteins
proteins
Chemical Engineering
protein engineering
33 Citations

Toward understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa

Eren, E., Parkin, J., Adelanwa, A., Cheneke, B., Movileanu, L., Khalid, S. & Van Den Berg, B., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12042-12053 12 p.

Research output: Contribution to journalArticle

Ion Channels
Pseudomonas aeruginosa
Ladders
Membranes
Molecules
2012
16 Citations

An outer membrane protein undergoes enthalpy- and entropy-driven transitions

Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L., Jul 3 2012, In : Biochemistry. 51, 26, p. 5348-5358 11 p.

Research output: Contribution to journalArticle

Entropy
Enthalpy
Membrane Proteins
Temperature
Chemical activation
20 Citations

Cation selectivity is a conserved feature in the OccD subfamily of Pseudomonas aeruginosa

Liu, J., Wolfe, A. J., Eren, E., Vijayaraghavan, J., Indic, M., Van Den Berg, B. & Movileanu, L., Nov 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2908-2916 9 p.

Research output: Contribution to journalArticle

Ion Channels
Pseudomonas aeruginosa
Cations
Membranes
Proteins
61 Citations

Engineering a rigid protein tunnel for biomolecular detection

Mohammad, M. M., Iyer, R., Howard, K. R., McPike, M. P., Borer, P. N. & Movileanu, L., Jun 6 2012, In : Journal of the American Chemical Society. 134, 22, p. 9521-9531 11 p.

Research output: Contribution to journalArticle

Tunnels
Nanopores
Proteins
Membrane Proteins
Nucleotide Aptamers
13 Citations

Inspection of the Engineered FhuA Δc/Δ4L Protein Nanopore by Polymer Exclusion

Niedzwiecki, D. J., Mohammad, M. M. & Movileanu, L., Nov 21 2012, In : Biophysical Journal. 103, 10, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Nanopores
Polymers
Ethylene Glycols
Protein Engineering
Proteins
27 Citations

OccK channels from pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity

Liu, J., Eren, E., Vijayaraghavan, J., Cheneke, B. R., Indic, M., Van Den Berg, B. & Movileanu, L., Mar 20 2012, In : Biochemistry. 51, 11, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Anions
Membrane Proteins
Conformations
Substrates
9 Citations

Protein sensing with engineered protein nanopores

Mohammad, M. M. & Movileanu, L., 2012, Methods in Molecular Biology. Vol. 870. p. 21-37 17 p. (Methods in Molecular Biology; vol. 870).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanopores
Hemolysin Proteins
Proteins
Peptides
Protein Transport
58 Citations

Substrate specificity within a family of outer membrane carboxylate channels

Eren, E., Vijayaraghavan, J., Liu, J., Cheneke, B. R., Touw, D. S., Lepore, B. W., Indic, M., Movileanu, L. & van den Berg, B., Jan 2012, In : PLoS biology.. 10, 1, e1001242.

Research output: Contribution to journalArticle

substrate specificity
Substrate Specificity
Ion Channels
Bacteria
antibiotics
2011
23 Citations

Analysis of gating transitions among the three major open states of the OpdK channel

Cheneke, B. R., Van Den Berg, B. & Movileanu, L., Jun 7 2011, In : Biochemistry. 50, 22, p. 4987-4997 11 p.

Research output: Contribution to journalArticle

Membrane Proteins
Porins
Lipid bilayers
Kinetics
Lipid Bilayers

Monitoring protein adsorption with solid-state nanopores

Niedzwiecki, D. J. & Movileanu, L., 2011, In : Journal of Visualized Experiments. 58, e3560.

Research output: Contribution to journalArticle

Nanopores
Adsorption
Proteins
Monitoring
Lab-On-A-Chip Devices
36 Citations

Redesign of a plugged β-barrel membrane protein

Mohammad, M. M., Howard, K. R. & Movileanu, L., Mar 11 2011, In : Journal of Biological Chemistry. 286, 10, p. 8000-8013 14 p.

Research output: Contribution to journalArticle

Membrane Proteins
Protein Engineering
Proteins
Bacterial Outer Membrane Proteins
Nanopores
2010
33 Citations

Facilitated translocation of polypeptides through a single nanopore

Bikwemu, R., Wolfe, A. J., Xing, X. & Movileanu, L., Nov 17 2010, In : Journal of Physics Condensed Matter. 22, 45, 454117.

Research output: Contribution to journalArticle

Nanopores
Polypeptides
polypeptides
Peptides
traps
28 Citations

Impact of distant charge reversals within a robust β-barrel protein pore

Mohammad, M. M. & Movileanu, L., Jul 8 2010, In : Journal of Physical Chemistry B. 114, 26, p. 8750-8759 10 p.

Research output: Contribution to journalArticle

Protein Engineering
Porins
Hemolysin Proteins
Lipid Bilayers
Aspartic Acid
76 Citations

Single-molecule observation of protein adsorption onto an inorganic surface

Niedzwiecki, D. J., Grazul, J. & Movileanu, L., Aug 11 2010, In : Journal of the American Chemical Society. 132, 31, p. 10816-10822 7 p.

Research output: Contribution to journalArticle

Nanopores
Adsorption
Observation
Proteins
Molecules
2009
121 Citations

Interrogating single proteins through nanopores: challenges and opportunities

Movileanu, L., Jun 2009, In : Trends in Biotechnology. 27, 6, p. 333-341 9 p.

Research output: Contribution to journalArticle

Nanopores
Proteins
Nanomedicine
Medical nanotechnology
Porins
2008
82 Citations

Controlling a single protein in a nanopore through electrostatic traps

Mohammad, M. M., Prakash, S., Matouschek, A. & Movileanu, L., Mar 26 2008, In : Journal of the American Chemical Society. 130, 12, p. 4081-4088 8 p.

Research output: Contribution to journalArticle

Nanopores
Static Electricity
Electrostatics
Porins
Proteins
35 Citations

Crystal Structure of the Outer Membrane Protein OpdK from Pseudomonas aeruginosa

Biswas, S., Mohammad, M. M., Movileanu, L. & van den Berg, B., Jul 9 2008, In : Structure. 16, 7, p. 1027-1035 9 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Membrane Proteins
Porins
Substrate Specificity
Gram-Negative Bacteria
53 Citations

Excursion of a single polypeptide into a protein pore: Simple physics, but complicated biology

Mohammad, M. M. & Movileanu, L., Jul 2008, In : European Biophysics Journal. 37, 6, p. 913-925 13 p.

Research output: Contribution to journalArticle

Porins
Physics
Peptides
Cytochromes b
Static Electricity
64 Citations

Squeezing a single polypeptide through a nanopore

Movileanu, L., 2008, In : Soft Matter. 4, 5, p. 925-931 7 p.

Research output: Contribution to journalArticle

Nanopores
polypeptides
compressing
proteins
Peptides
50 Citations

Transport at the nanoscale: Temperature dependence of ion conductance

Chimerel, C., Movileanu, L., Pezeshki, S., Winterhalter, M. & Kleinekathöfer, U., Nov 2008, In : European Biophysics Journal. 38, 1, p. 121-125 5 p.

Research output: Contribution to journalArticle

Nanopores
Ion Transport
Ions
Temperature
Salts
2007
107 Citations

Catalyzing the translocation of polypeptides through attractive interactions

Wolfe, A. J., Mohammad, M. M., Cheley, S., Bayley, H. & Movileanu, L., Nov 14 2007, In : Journal of the American Chemical Society. 129, 45, p. 14034-14041 8 p.

Research output: Contribution to journalArticle

Polypeptides
Binding sites
Peptides
Binding Sites
Proteins
70 Citations

Single-molecule electrophoresis of β-hairpin peptides by electrical recordings and Langevin dynamics simulations

Goodrich, C. P., Kirmizialtin, S., Huyghues-Despointes, B. M., Zhu, A., Scholtz, J. M., Makarov, D. E. & Movileanu, L., Apr 5 2007, In : Journal of Physical Chemistry B. 111, 13, p. 3332-3335 4 p.

Research output: Contribution to journalArticle

electrophoresis
Electrophoresis
Peptides
peptides
recording
65 Citations

Structural insight into OprD substrate specificity

Biswas, S., Mohammad, M. M., Patel, D. R., Movileanu, L. & Van Den Berg, B., Nov 2007, In : Nature Structural and Molecular Biology. 14, 11, p. 1108-1109 2 p.

Research output: Contribution to journalArticle

Substrate Specificity
Gram-Negative Bacteria
Ion Channels
Constriction
Pseudomonas aeruginosa
2006
90 Citations

Temperature-responsive protein pores

Jung, Y., Bayley, H. & Movileanu, L., Nov 29 2006, In : Journal of the American Chemical Society. 128, 47, p. 15332-15340 9 p.

Research output: Contribution to journalArticle

Elastin
Porins
Polypeptides
Proteins
Peptides
14 Citations

Transbilayer pores induced by thickness fluctuations

Movileanu, L., Popescu, D., Ion, S. & Popescu, A. I., Aug 2006, In : Bulletin of Mathematical Biology. 68, 6, p. 1231-1255 25 p.

Research output: Contribution to journalArticle

Phospholipids
phospholipid
phospholipids
Fluctuations
Unstable
2005
38 Citations

Ethanol-induced alterations of the antioxidant defense system in rat kidney

Dinu, D., Nechifor, M. T. & Movileanu, L., 2005, In : Journal of Biochemical and Molecular Toxicology. 19, 6, p. 386-395 10 p.

Research output: Contribution to journalArticle

Rats
Ethanol
Antioxidants
Kidney
Glutathione Reductase
177 Citations

Interactions of peptides with a protein pore

Movileanu, L., Schmittschmitt, J. P., Scholtz, J. M. & Bayley, H., Aug 2005, In : Biophysical Journal. 89, 2, p. 1030-1045 16 p.

Research output: Contribution to journalArticle

Porins
Peptides
Hemolysin Proteins
Membrane Potentials
Nuclear Pore Complex Proteins
2003
3 Citations

Chapter 5 Elastic properties of bilayer lipid membranes and pore formation

Popescu, D., Ion, S., Popescu, A. & Movileanu, L., 2003, In : Membrane Science and Technology. 7, C, p. 173-204 32 p.

Research output: Contribution to journalArticle

Lipid bilayers
Membrane Lipids
78 Citations

Partitioning of individual flexible polymers into a nanoscopic protein pore

Movileanu, L., Cheley, S. & Bayley, H., Aug 1 2003, In : Biophysical Journal. 85, 2, p. 897-910 14 p.

Research output: Contribution to journalArticle

Porins
Polymers
Hemolysin Proteins
Ethylene Glycol
Biotechnology
2002
5 Citations

Comparative study of some energetic and steric parameters of the wild type and mutants HIV-1 protease: A way to explain the viral resistance

Avram, S., Movileanu, L., Mihailescu, D. & Flonta, M. L., Apr 2002, In : Journal of Cellular and Molecular Medicine. 6, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

HIV-1
Static Electricity
Electrostatics
Mutation
Information Storage and Retrieval
33 Citations

Determination of base and backbone contributions to the thermodynamics of premelting and melting transitions in B DNA

Movileanu, L., Benevides, J. M. & Thomas, G. J., Sep 1 2002, In : Nucleic Acids Research. 30, 17, p. 3767-3777 11 p.

Research output: Contribution to journalArticle

Thermodynamics
Poly dA-dT
Freezing
DNA
Base Pairing
94 Citations

Subunit composition of a bicomponent toxin: Staphylococcal leukocidin forms an octameric transmembrane pore

Miles, G., Movileanu, L. & Bayley, H., 2002, In : Protein Science. 11, 4, p. 894-902 9 p.

Research output: Contribution to journalArticle

Leukocidins
Chemical analysis
Protein Engineering
Hemolysin Proteins
Chemical modification