• 1600 Citations
  • 19 h-Index
1988 …2019
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Research Output 1988 2019

  • 1600 Citations
  • 19 h-Index
  • 36 Article
  • 2 Chapter
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Article
2019
Open Access
AMPA Receptors
Pentylenetetrazole
Cysteine
Glutamic Acid
Epilepsy
2018
1 Citation (Scopus)
Cyclooxygenase 2
Seizures
Maintenance
T-Lymphocytes
Antigens
1 Citation (Scopus)

Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

Kanzler, M. A., Van Dyke, A. M., He, Y., Hewett, J. & Hewett, S., Jan 1 2018, In : Epilepsia Open. 3, 2, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
Mortality
Seizures
12-15-lipoxygenase
Messenger RNA
Pentylenetetrazole
2016
5 Citations (Scopus)
RNA-Binding Proteins
Interleukin-1
Astrocytes
Substrates
Messenger RNA
7 Citations (Scopus)
Cyclic AMP Response Element-Binding Protein
Neurons
Transcription Factors
Luciferases
Prostaglandin-Endoperoxide Synthases
2015
2 Citations (Scopus)

A cytotoxic, co-operative interaction between energy deprivation and glutamate release from system xc -mediates aglycemic neuronal cell death

Thorn, T. L., He, Y., Jackman, N. A., Lobner, D., Hewett, J. & Hewett, S., Nov 9 2015, In : ASN Neuro. 7, 6

Research output: Contribution to journalArticle

Astrocytes
Glutamic Acid
Cell Death
Glucose
Antiporters
2012
19 Citations (Scopus)

Neuromodulatory role of endogenous interleukin-1β in acute seizures: Possible contribution of cyclooxygenase-2

Claycomb, R. J., Hewett, S. & Hewett, J., Jan 2012, In : Neurobiology of Disease. 45, 1, p. 234-242 9 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Interleukin-1
Seizures
Pentylenetetrazole
Kainic Acid
14 Citations (Scopus)

Non-cell autonomous influence of the astrocyte system X - c on hypoglycaemic neuronal cell death

Jackman, N. A., Melchior, S. E., Hewett, J. & Hewett, S., 2012, In : ASN Neuro. 4, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Astrocytes
Cell Death
Cystine
Glucose

Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death.

Jackman, N. A., Melchior, S. E., Hewett, J. A. & Hewett, S. J., 2012, In : ASN Neuro. 4, 1

Research output: Contribution to journalArticle

Hypoglycemic Agents
Astrocytes
Cell Death
Cystine
Glutamic Acid
2011
22 Citations (Scopus)

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition

Claycomb, R. J., Hewett, S. & Hewett, J., Feb 2011, In : Epilepsia. 52, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

Pentylenetetrazole
Meals
Seizures
Cyclooxygenase 2
Maintenance
2010

Analysis and function of lipid mediators in the nervous system

Hewett, J., Fuss, B. & Hewett, S., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 61-62 2 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Arachidonic Acid
Nervous System
Signal Transduction
Lipids
53 Citations (Scopus)

Regulation of system xc -activity and expression in astrocytes by interleukin-1β: Implications for hypoxic neuronal injury

Jackman, N. A., Uliasz, T. F., Hewett, J. & Hewett, S., Nov 15 2010, In : GLIA. 58, 15, p. 1806-1815 10 p.

Research output: Contribution to journalArticle

Interleukin-1
Astrocytes
Cystine
Wounds and Injuries
Amino Acid Transport Systems
14 Citations (Scopus)

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression

Hamby, M. E., Hewett, J. & Hewett, S., Aug 15 2010, In : GLIA. 58, 11, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Astrocytes
Activins
Phosphotransferases
Nitric Oxide
2009
71 Citations (Scopus)
Neurology
Astrocytes
Central Nervous System
Neuroglia
Population
2008
12 Citations (Scopus)

Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death

Taylor, A. L., Bonventre, J. V., Uliasz, T. F., Hewett, J. & Hewett, S., Aug 2008, In : Journal of Neurochemistry. 106, 4, p. 1828-1840 13 p.

Research output: Contribution to journalArticle

Cytosolic Phospholipases A2
Cell death
N-Methyl-D-Aspartate Receptors
Arachidonic Acid
Prostaglandins
19 Citations (Scopus)

TGFβ1 and TNFα potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2

Hamby, M. E., Gragnolati, A. R., Hewett, S. & Hewett, J., May 2008, In : Neurochemistry International. 52, 6, p. 962-971 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Nitric Oxide Synthase
Astrocytes
Nitric Oxide
Tumor Necrosis Factor-alpha
10 Citations (Scopus)
Transforming Growth Factors
Cyclooxygenase 2
Gene expression
Nitric Oxide Synthase
Gene Expression
2006
86 Citations (Scopus)

Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes

Hamby, M. E., Uliasz, T. F., Hewett, S. & Hewett, J., Jan 15 2006, In : Journal of Neuroscience Methods. 150, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Cell Separation
Cyclooxygenase 2
Nitric Oxide Synthase
65 Citations (Scopus)

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system

Hewett, S., Bell, S. C. & Hewett, J., Nov 2006, In : Pharmacology and Therapeutics. 112, 2, p. 335-357 23 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Central Nervous System
Arachidonic Acid
29 Citations (Scopus)

Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration

Hewett, S., Silakova, J. M. & Hewett, J., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 3, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

N-Methylaspartate
Dentate Gyrus
Wounds and Injuries
Rodent Control
Diet
49 Citations (Scopus)

TGF-β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2

Hamby, M. E., Hewett, J. & Hewett, S., Nov 2006, In : GLIA. 54, 6, p. 566-577 12 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Nitric Oxide Synthase
Astrocytes
Nitric Oxide
Lipopolysaccharides
2005
59 Citations (Scopus)

Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat

Snipes, J. A., Kis, B., Shelness, G. S., Hewett, J. & Busija, D. W., May 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 2, p. 668-676 9 p.

Research output: Contribution to journalArticle

Organism Cloning
Prostaglandin-Endoperoxide Synthases
Cyclooxygenase 1
Proteins
COS Cells
27 Citations (Scopus)

Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation

Fogal, B., Hewett, J. & Hewett, S., Apr 2005, In : Journal of Neuroimmunology. 161, 1-2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Interleukin-1
Wounds and Injuries
Oxygen
Glucose
Neutralizing Antibodies
2004
26 Citations (Scopus)

Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window

Silakova, J. M., Hewett, J. & Hewett, S., Jun 2004, In : Journal of Pharmacology and Experimental Therapeutics. 309, 3, p. 1060-1066 7 p.

Research output: Contribution to journalArticle

Naproxen
N-Methylaspartate
Brain Edema
Microinjections
N-Methyl-D-Aspartate Receptors
2001
22 Citations (Scopus)

Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells

Vidwans, A. S., Uliasz, T. F., Hewett, J. & Hewett, S., Sep 25 2001, In : Biochemistry. 40, 38, p. 11533-11542 10 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Nitric Oxide
Modulation
Oxidation-Reduction
Prostaglandins
2000
217 Citations (Scopus)

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture

Hewett, S., Uliasz, T. F., Vidwans, A. S. & Hewett, J., May 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 2, p. 417-425 9 p.

Research output: Contribution to journalArticle

Primary Cell Culture
N-Methylaspartate
Cyclooxygenase 2
Cell Death
Flurbiprofen
1999
2 Citations (Scopus)
Oligodendroglia
Microglia
Nitric Oxide Synthase Type II
Neurosciences
Research
48 Citations (Scopus)

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia

Hewett, J., Hewett, S., Winkler, S. & Pfeiffer, S. E., May 1 1999, In : Journal of Neuroscience Research. 56, 2, p. 189-198 10 p.

Research output: Contribution to journalArticle

Oligodendroglia
Microglia
Nitric Oxide Synthase Type II
Lipopolysaccharides
Nitric Oxide
1995
48 Citations (Scopus)
Gram-Negative Bacteria
Fibrinogen
Lipopolysaccharides
Liver
Wounds and Injuries
1994
7 Citations (Scopus)

Methylene Dianiline Hepatotoxicity Is Not Leukocyte-Dependent

Bailie, M. B., Hewett, J., Schultze, A. E. & Roth, R. A., Jan 1994, In : Toxicology and Applied Pharmacology. 124, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

Liver
Leukocytes
Cyclophosphamide
Rats
Infiltration
1993
255 Citations (Scopus)

Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides

Hewett, J. & Roth, R. A., Dec 1993, In : Pharmacological Reviews. 45, 4, p. 381-411 31 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Liver
Thrombin
Thromboxane A2
Blood Platelets
141 Citations (Scopus)

Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury

Hewett, J., Jean, P. A., Kunkel, S. L. & Roth, R. A., 1993, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 265, 6 28-6

Research output: Contribution to journalArticle

Endotoxins
Lipopolysaccharides
Neutrophils
Tumor Necrosis Factor-alpha
Liver
1992
164 Citations (Scopus)

Neutrophil depletion protects against liver injury from bacterial endotoxin

Hewett, J., Schultze, A. E., VanCise, S. & Roth, R. A., 1992, In : Laboratory Investigation. 66, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

Endotoxins
Lipopolysaccharides
Neutrophils
Liver
Wounds and Injuries
1990
18 Citations (Scopus)

The cholestatic agent, α-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro

Roth, R. A. & Hewett, J., 1990, In : Laboratory Investigation. 62, 6, p. 736-741 6 p.

Research output: Contribution to journalArticle

Superoxides
Neutrophils
Proadifen
Trypan Blue
Peritoneum
1988
41 Citations (Scopus)

Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils

Dahm, L. J., Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 95, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Bile
Superoxides
Rats
Neutrophils
24 Citations (Scopus)

Dieldrin activates rat neutrophils in vitro

Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 96, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

Dieldrin
Rats
Neutrophils
Superoxides
leucyl-phenylalanine