• 1600 Citations
  • 19 h-Index
1988 …2019

Research output per year

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Research Output

  • 1600 Citations
  • 19 h-Index
  • 36 Article
  • 2 Chapter
Article

A cytotoxic, co-operative interaction between energy deprivation and glutamate release from system xc -mediates aglycemic neuronal cell death

Thorn, T. L., He, Y., Jackman, N. A., Lobner, D., Hewett, J. & Hewett, S., Nov 9 2015, In : ASN Neuro. 7, 6

Research output: Contribution to journalArticle

2 Scopus citations

Analysis and function of lipid mediators in the nervous system

Hewett, J., Fuss, B. & Hewett, S., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 61-62 2 p.

Research output: Contribution to journalArticle

Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils

Dahm, L. J., Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 95, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes

Hamby, M. E., Uliasz, T. F., Hewett, S. & Hewett, J., Jan 15 2006, In : Journal of Neuroscience Methods. 150, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat

Snipes, J. A., Kis, B., Shelness, G. S., Hewett, J. & Busija, D. W., May 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 2, p. 668-676 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system

Hewett, S., Bell, S. C. & Hewett, J., Nov 2006, In : Pharmacology and Therapeutics. 112, 2, p. 335-357 23 p.

Research output: Contribution to journalArticle

65 Scopus citations

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture

Hewett, S., Uliasz, T. F., Vidwans, A. S. & Hewett, J., May 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 2, p. 417-425 9 p.

Research output: Contribution to journalArticle

217 Scopus citations

Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death

Taylor, A. L., Bonventre, J. V., Uliasz, T. F., Hewett, J. & Hewett, S., Aug 2008, In : Journal of Neurochemistry. 106, 4, p. 1828-1840 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
Open Access
71 Scopus citations

Dieldrin activates rat neutrophils in vitro

Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 96, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells

Vidwans, A. S., Uliasz, T. F., Hewett, J. & Hewett, S., Sep 25 2001, In : Biochemistry. 40, 38, p. 11533-11542 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides

Hewett, J. & Roth, R. A., Dec 1993, In : Pharmacological Reviews. 45, 4, p. 381-411 31 p.

Research output: Contribution to journalArticle

255 Scopus citations

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia

Hewett, J., Hewett, S., Winkler, S. & Pfeiffer, S. E., May 1 1999, In : Journal of Neuroscience Research. 56, 2, p. 189-198 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation

Fogal, B., Hewett, J. & Hewett, S., Apr 2005, In : Journal of Neuroimmunology. 161, 1-2, p. 93-100 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
5 Scopus citations
1 Scopus citations

Methylene Dianiline Hepatotoxicity Is Not Leukocyte-Dependent

Bailie, M. B., Hewett, J., Schultze, A. E. & Roth, R. A., Jan 1994, In : Toxicology and Applied Pharmacology. 124, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

Kanzler, M. A., Van Dyke, A. M., He, Y., Hewett, J. & Hewett, S., Jan 1 2018, In : Epilepsia Open. 3, 2, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window

Silakova, J. M., Hewett, J. & Hewett, S., Jun 2004, In : Journal of Pharmacology and Experimental Therapeutics. 309, 3, p. 1060-1066 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Neuromodulatory role of endogenous interleukin-1β in acute seizures: Possible contribution of cyclooxygenase-2

Claycomb, R. J., Hewett, S. & Hewett, J., Jan 2012, In : Neurobiology of Disease. 45, 1, p. 234-242 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Neutrophil depletion protects against liver injury from bacterial endotoxin

Hewett, J., Schultze, A. E., VanCise, S. & Roth, R. A., 1992, In : Laboratory Investigation. 66, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

164 Scopus citations

Non-cell autonomous influence of the astrocyte system X - c on hypoglycaemic neuronal cell death

Jackman, N. A., Melchior, S. E., Hewett, J. & Hewett, S., 2012, In : ASN Neuro. 4, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death.

Jackman, N. A., Melchior, S. E., Hewett, J. A. & Hewett, S. J., 2012, In : ASN Neuro. 4, 1

Research output: Contribution to journalArticle

Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration

Hewett, S., Silakova, J. M. & Hewett, J., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 3, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition

Claycomb, R. J., Hewett, S. & Hewett, J., Feb 2011, In : Epilepsia. 52, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Regulation of system xc -activity and expression in astrocytes by interleukin-1β: Implications for hypoxic neuronal injury

Jackman, N. A., Uliasz, T. F., Hewett, J. & Hewett, S., Nov 15 2010, In : GLIA. 58, 15, p. 1806-1815 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury

Hewett, J., Jean, P. A., Kunkel, S. L. & Roth, R. A., 1993, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 265, 6 28-6

Research output: Contribution to journalArticle

141 Scopus citations

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression

Hamby, M. E., Hewett, J. & Hewett, S., Aug 15 2010, In : GLIA. 58, 11, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
7 Scopus citations

TGFβ1 and TNFα potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2

Hamby, M. E., Gragnolati, A. R., Hewett, S. & Hewett, J., May 2008, In : Neurochemistry International. 52, 6, p. 962-971 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

TGF-β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2

Hamby, M. E., Hewett, J. & Hewett, S., Nov 2006, In : GLIA. 54, 6, p. 566-577 12 p.

Research output: Contribution to journalArticle

49 Scopus citations
10 Scopus citations

The cholestatic agent, α-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro

Roth, R. A. & Hewett, J., 1990, In : Laboratory Investigation. 62, 6, p. 736-741 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
48 Scopus citations
Chapter

Generation of primary astrocyte cultures devoid of contaminating microglia

Uliasz, T. F., Hamby, M. E., Jackman, N. A., Hewett, J. & Hewett, S., 2012, Methods in Molecular Biology. Vol. 814. p. 61-79 19 p. (Methods in Molecular Biology; vol. 814).

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures

Hewett, J. & Hewett, S., 2012, Methods in Molecular Biology. Vol. 814. p. 251-263 13 p. (Methods in Molecular Biology; vol. 814).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations