• 1600 Citations
  • 19 h-Index
1988 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1600 Citations
  • 19 h-Index
  • 36 Article
  • 2 Chapter
2019
Open Access
2018
1 Scopus citations

Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

Kanzler, M. A., Van Dyke, A. M., He, Y., Hewett, J. & Hewett, S., Jan 1 2018, In : Epilepsia Open. 3, 2, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016
5 Scopus citations
7 Scopus citations
2015

A cytotoxic, co-operative interaction between energy deprivation and glutamate release from system xc -mediates aglycemic neuronal cell death

Thorn, T. L., He, Y., Jackman, N. A., Lobner, D., Hewett, J. & Hewett, S., Nov 9 2015, In : ASN Neuro. 7, 6

Research output: Contribution to journalArticle

2 Scopus citations
2012

Generation of primary astrocyte cultures devoid of contaminating microglia

Uliasz, T. F., Hamby, M. E., Jackman, N. A., Hewett, J. & Hewett, S., 2012, Methods in Molecular Biology. Vol. 814. p. 61-79 19 p. (Methods in Molecular Biology; vol. 814).

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures

Hewett, J. & Hewett, S., 2012, Methods in Molecular Biology. Vol. 814. p. 251-263 13 p. (Methods in Molecular Biology; vol. 814).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Neuromodulatory role of endogenous interleukin-1β in acute seizures: Possible contribution of cyclooxygenase-2

Claycomb, R. J., Hewett, S. & Hewett, J., Jan 2012, In : Neurobiology of Disease. 45, 1, p. 234-242 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Non-cell autonomous influence of the astrocyte system X - c on hypoglycaemic neuronal cell death

Jackman, N. A., Melchior, S. E., Hewett, J. & Hewett, S., 2012, In : ASN Neuro. 4, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death.

Jackman, N. A., Melchior, S. E., Hewett, J. A. & Hewett, S. J., 2012, In : ASN Neuro. 4, 1

Research output: Contribution to journalArticle

2011

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition

Claycomb, R. J., Hewett, S. & Hewett, J., Feb 2011, In : Epilepsia. 52, 2, p. 273-283 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Analysis and function of lipid mediators in the nervous system

Hewett, J., Fuss, B. & Hewett, S., Apr 2010, In : Prostaglandins and Other Lipid Mediators. 91, 3-4, p. 61-62 2 p.

Research output: Contribution to journalArticle

Regulation of system xc -activity and expression in astrocytes by interleukin-1β: Implications for hypoxic neuronal injury

Jackman, N. A., Uliasz, T. F., Hewett, J. & Hewett, S., Nov 15 2010, In : GLIA. 58, 15, p. 1806-1815 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression

Hamby, M. E., Hewett, J. & Hewett, S., Aug 15 2010, In : GLIA. 58, 11, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009
71 Scopus citations
2008

Cytosolic phospholipase A2α inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death

Taylor, A. L., Bonventre, J. V., Uliasz, T. F., Hewett, J. & Hewett, S., Aug 2008, In : Journal of Neurochemistry. 106, 4, p. 1828-1840 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

TGFβ1 and TNFα potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2

Hamby, M. E., Gragnolati, A. R., Hewett, S. & Hewett, J., May 2008, In : Neurochemistry International. 52, 6, p. 962-971 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
10 Scopus citations
2006

Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes

Hamby, M. E., Uliasz, T. F., Hewett, S. & Hewett, J., Jan 15 2006, In : Journal of Neuroscience Methods. 150, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

86 Scopus citations

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system

Hewett, S., Bell, S. C. & Hewett, J., Nov 2006, In : Pharmacology and Therapeutics. 112, 2, p. 335-357 23 p.

Research output: Contribution to journalArticle

65 Scopus citations

Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration

Hewett, S., Silakova, J. M. & Hewett, J., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 3, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

TGF-β1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2

Hamby, M. E., Hewett, J. & Hewett, S., Nov 2006, In : GLIA. 54, 6, p. 566-577 12 p.

Research output: Contribution to journalArticle

49 Scopus citations
2005

Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat

Snipes, J. A., Kis, B., Shelness, G. S., Hewett, J. & Busija, D. W., May 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 2, p. 668-676 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Interleukin-1β potentiates neuronal injury in a variety of injury models involving energy deprivation

Fogal, B., Hewett, J. & Hewett, S., Apr 2005, In : Journal of Neuroimmunology. 161, 1-2, p. 93-100 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2004

Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window

Silakova, J. M., Hewett, J. & Hewett, S., Jun 2004, In : Journal of Pharmacology and Experimental Therapeutics. 309, 3, p. 1060-1066 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2001

Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells

Vidwans, A. S., Uliasz, T. F., Hewett, J. & Hewett, S., Sep 25 2001, In : Biochemistry. 40, 38, p. 11533-11542 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2000

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture

Hewett, S., Uliasz, T. F., Vidwans, A. S. & Hewett, J., May 2000, In : Journal of Pharmacology and Experimental Therapeutics. 293, 2, p. 417-425 9 p.

Research output: Contribution to journalArticle

217 Scopus citations

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia

Hewett, J., Hewett, S., Winkler, S. & Pfeiffer, S. E., May 1 1999, In : Journal of Neuroscience Research. 56, 2, p. 189-198 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
1995
48 Scopus citations
1994

Methylene Dianiline Hepatotoxicity Is Not Leukocyte-Dependent

Bailie, M. B., Hewett, J., Schultze, A. E. & Roth, R. A., Jan 1994, In : Toxicology and Applied Pharmacology. 124, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
1993

Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides

Hewett, J. & Roth, R. A., Dec 1993, In : Pharmacological Reviews. 45, 4, p. 381-411 31 p.

Research output: Contribution to journalArticle

255 Scopus citations

Relationship between tumor necrosis factor-α and neutrophils in endotoxin-induced liver injury

Hewett, J., Jean, P. A., Kunkel, S. L. & Roth, R. A., 1993, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 265, 6 28-6

Research output: Contribution to journalArticle

141 Scopus citations
1992

Neutrophil depletion protects against liver injury from bacterial endotoxin

Hewett, J., Schultze, A. E., VanCise, S. & Roth, R. A., 1992, In : Laboratory Investigation. 66, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

164 Scopus citations
1990

The cholestatic agent, α-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro

Roth, R. A. & Hewett, J., 1990, In : Laboratory Investigation. 62, 6, p. 736-741 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
1988

Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils

Dahm, L. J., Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 95, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Dieldrin activates rat neutrophils in vitro

Hewett, J. & Roth, R. A., 1988, In : Toxicology and Applied Pharmacology. 96, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

24 Scopus citations