• 559 Citations
  • 13 h-Index
20062023
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Research Output 2006 2019

2019

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

Nath, D., Li, X., Mondragon, C., Post, D., Chen, M., White, J. R., Hryniewicz-Jankowska, A., Caza, T., Kuznetsov, V. A., Hehnly, H., Jamaspishvili, T., Berman, D. M., Zhang, F., Kung, S. H. Y., Fazli, L., Gleave, M. E., Bratslavsky, G., Pandolfi, P. P. & Kotula, L., Sep 18 2019, In : Cell Communication and Signaling. 17, 1, 120.

Research output: Contribution to journalArticle

Open Access
Epithelial-Mesenchymal Transition
Tumors
Prostate
Carcinogenesis
Chemical activation
5 Citations (Scopus)

ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

Dao, T. P., Martyniak, B., Canning, A. J., Lei, Y., Colicino, E. G., Cosgrove, M. S., Hehnly, H. & Castaneda, C., Jun 4 2019, In : Structure. 27, 6, p. 937-951.e5

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Amino Acids
Mutation
X-Linked Genes
Ultracentrifugation

Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes

Colicino, E. G., Stevens, K., Curtis, E., Rathbun, L., Bates, M., Manikas, J., Amack, J., Freshour, J. & Hehnly, H., Jun 15 2019, In : Molecular biology of the cell. 30, 13, p. 1598-1609 12 p.

Research output: Contribution to journalArticle

Open Access
Spindle Poles
Centrosome
Chromosomes
Centrioles
Spindle Apparatus
3 Citations (Scopus)

The balance between adhesion and contraction during cell division

Taneja, N., Rathbun, L., Hehnly, H. & Burnette, D. T., Feb 1 2019, In : Current Opinion in Cell Biology. 56, p. 45-52 8 p.

Research output: Contribution to journalReview article

Cell Division
Centrosome
Spindle Apparatus
Microtubules
Embryonic Development
2018
3 Citations (Scopus)

Gravin regulates centrosome function through PLK1

Colicino, E. G., Garrastegui, A. M., Freshour, J., Santra, P., Post, D. E., Kotula, L. & Hehnly, H., Mar 1 2018, In : Molecular Biology of the Cell. 29, 5, p. 532-541 10 p.

Research output: Contribution to journalArticle

Centrosome
Chromosome Segregation
Chromosomes
Kinetochores
Biosensing Techniques
4 Citations (Scopus)

New dimensions of asymmetric division in vertebrates

Vertii, A., Kaufman, P. D., Hehnly, H. & Doxsey, S., Mar 1 2018, In : Cytoskeleton. 75, 3, p. 87-102 16 p.

Research output: Contribution to journalReview article

Asymmetric Cell Division
Vertebrates
Cell Division
Centrosome
Untranslated RNA
4 Citations (Scopus)

Regulating a key mitotic regulator, polo-like kinase 1 (PLK1)

Colicino, E. G. & Hehnly, H., Jan 1 2018, (Accepted/In press) In : Cytoskeleton.

Research output: Contribution to journalArticle

Mitosis
Cell Division
Phosphotransferases
M Phase Cell Cycle Checkpoints
Kinetochores
2016
5 Citations (Scopus)

Erratum: The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation (Current Biology (2016) 26 (793-801)

Hung, H. F., Hehnly, H. & Doxsey, S., May 9 2016, In : Current Biology. 26, 9, 1 p.

Research output: Contribution to journalComment/debate

Proteins
10 Citations (Scopus)

Focal adhesions control cleavage furrow shape and spindle tilt during mitosis

Taneja, N., Fenix, A. M., Rathbun, L., Millis, B. A., Tyska, M. J., Hehnly, H. & Burnette, D. T., Jul 19 2016, In : Scientific Reports. 6, 29846.

Research output: Contribution to journalArticle

Focal Adhesions
Mitosis
Stem Cells
Paxillin
Vinculin
28 Citations (Scopus)

The centrosome, a multitalented renaissance organelle

Vertii, A., Hehnly, H. & Doxsey, S., Jan 1 2016, In : Cold Spring Harbor perspectives in biology. 8, 12, a025049.

Research output: Contribution to journalArticle

Centrosome
Organelles
Recycling
Endosomes
Cells
7 Citations (Scopus)

The Centrosome Undergoes Plk1-Independent Interphase Maturation during Inflammation and Mediates Cytokine Release

Vertii, A., Ivshina, M., Zimmerman, W., Hehnly, H., Kant, S. & Doxsey, S., May 23 2016, In : Developmental Cell. 37, 4, p. 377-386 10 p.

Research output: Contribution to journalArticle

Centrosome
Interphase
Cytokines
Inflammation
Phosphotransferases
12 Citations (Scopus)

The mother centriole appendage protein cenexin modulates lumen formation through spindle orientation

Hung, H. F., Hehnly, H. & Doxsey, S., Mar 21 2016, In : Current Biology. 26, 6, p. 793-801 9 p.

Research output: Contribution to journalArticle

Centrioles
centrioles
appendages
Microtubules
microtubules
2015
21 Citations (Scopus)

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

Hehnly, H., Canton, D., Bucko, P., Langeberg, L. K., Ogier, L., Gelman, I., Fernando Santana, L., Wordeman, L. & Scott, J. D., Sep 25 2015, In : eLife. 4, September, e09384.

Research output: Contribution to journalArticle

Spindle Poles
Seminoma
Spindle Apparatus
Seminiferous Tubules
Stem cells
3 Citations (Scopus)

Human Nek7-interactor RGS2 is required for mitotic spindle organization

De Souza, E. E., Hehnly, H., Perez, A. M., Meirelles, G. V., Smetana, J. H. C., Doxsey, S. & Kobarg, J., Feb 15 2015, In : Cell Cycle. 14, 4, p. 656-667 12 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Spindle Poles
Microtubules
Phosphotransferases
Kinetochores
2 Citations (Scopus)

Methods to analyze novel liaisons between endosomes and centrosomes

Hung, H. F., Hehnly, H. & Doxsey, S., Jan 1 2015, Methods in Cell Biology: Sorting and Recycling Endosomes, 2015. Guo, W. (ed.). Academic Press Inc., p. 47-58 12 p. (Methods in Cell Biology; vol. 130).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Centrosome
Endosomes
Recycling
Interphase
Spindle Poles
18 Citations (Scopus)

New frontiers: Discovering cilia-independent functions of cilia proteins

Vertii, A., Bright, A., Delaval, B., Hehnly, H. & Doxsey, S., Oct 1 2015, In : EMBO Reports. 16, 10, p. 1275-1287 13 p.

Research output: Contribution to journalReview article

Cilia
Centrosome
Poles
Proteins
Spindle Poles
21 Citations (Scopus)

PKA-Type i Selective Constrained Peptide Disruptors of AKAP Complexes

Wang, Y., Ho, T. G., Franz, E., Hermann, J. S., Smith, F. D., Hehnly, H., Esseltine, J. L., Hanold, L. E., Murph, M. M., Bertinetti, D., Scott, J. D., Herberg, F. W. & Kennedy, E. J., Jun 19 2015, In : ACS Chemical Biology. 10, 6, p. 1502-1510 9 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Peptides
Protein Isoforms
Proteins
2014
6 Citations (Scopus)

A new role for Rab GTPases during early mitotic stages

Das, S., Hehnly, H. & Doxsey, S., Jan 1 2014, In : Small GTPases. 5, JUNE, e29565.

Research output: Contribution to journalComment/debate

rab GTP-Binding Proteins
Spindle Poles
Mitosis
Poles
Spindle Apparatus
6 Citations (Scopus)

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

Gammon, D. B., Duraffour, S., Rozelle, D. K., Hehnly, H., Sharma, R., Sparks, M. E., West, C. C., Chen, Y., Moresco, J. J., Andrei, G., Connor, J. H., Conte, D., Gundersen-Rindal, D. E., Marshall, W. L., Yates, J. R., Silverman, N. & Mello, C. C., Jun 25 2014, In : eLife. 2014, 3, 02190.

Research output: Contribution to journalArticle

RNA Virus Infections
DNA Viruses
Invertebrates
Viruses
Vertebrates
41 Citations (Scopus)

A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

Chen, C. T., Hehnly, H., Yu, Q., Farkas, D., Zheng, G., Redick, S. D., Hung, H. F., Samtani, R., Jurczyk, A., Akbarian, S., Wise, C., Jackson, A., Bober, M., Guo, Y., Lo, C. & Doxsey, S., Jan 1 2014, In : Current Biology. 24, 19, p. 2327-2334 8 p.

Research output: Contribution to journalArticle

Spindle Poles
centrosomes
Centrosome
dwarfing
Poles

Erratum: A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation (Current Biology (2014) 24 (2327-2334))

Chen, C. T., Hehnly, H., Yu, Q., Farkas, D., Zheng, G., Redick, S. D., Hung, H. F., Samtani, R., Jurczyk, A., Akbarian, S., Wise, C., Jackson, A., Bober, M., Guo, Y., Lo, C. & Doxsey, S., Jan 1 2014, In : Current Biology. 24, 19, 1 p.

Research output: Contribution to journalComment/debate

Poles
Proteins
pericentrin

Erratum: A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation (Current Biology (2014) 24 (2327-2334))

Chen, C. T., Hehnly, H., Yu, Q., Farkas, D., Zheng, G., Redick, S. D., Hung, H. F., Samtani, R., Jurczyk, A., Akbarian, S., Wise, C., Jackson, A., Bober, M., Guo, Y., Lo, C. & Doxsey, S., Jan 1 2014, In : Current Biology. 24, 24, 1 p.

Research output: Contribution to journalComment/debate

Poles
Proteins
pericentrin
65 Citations (Scopus)

Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation

Hehnly, H. & Doxsey, S., Mar 10 2014, In : Developmental Cell. 28, 5, p. 497-507 11 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Endosomes
Spindle Poles
Poles
Mitosis
2013
6 Citations (Scopus)

One among many: ODF2 isoform 9, a.k.a. Cenexin-1, is required for ciliogenesis

Hehnly, H., Hung, H. F. & Doxsey, S., Apr 1 2013, In : Cell Cycle. 12, 7, 1 p.

Research output: Contribution to journalComment/debate

Protein Isoforms
2012

Multiplying madly: Deacetylases take charge of centrosome duplication and amplification

Hung, H. F., Hehnly, H. & Doxsey, S., Dec 1 2012, In : Cell Cycle. 11, 23, 1 p.

Research output: Contribution to journalComment/debate

Centrosome
30 Citations (Scopus)

Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Chen, C. T., Hehnly, H. & Doxsey, S. J., Aug 1 2012, In : Nature Reviews Molecular Cell Biology. 13, 8, p. 483-488 6 p.

Research output: Contribution to journalReview article

Endosomal Sorting Complexes Required for Transport
Nuclear Pore
Transport Vesicles
Cell Separation
Secretory Vesicles
14 Citations (Scopus)

Polarity sets the stage for cytokinesis

Hehnly, H. & Doxsey, S., Jan 1 2012, In : Molecular Biology of the Cell. 23, 1, p. 7-11 5 p.

Research output: Contribution to journalReview article

Cytokinesis
Cell Polarity
Membranes
Cell Separation
Chemotaxis
67 Citations (Scopus)

The centrosome regulates the Rab11- dependent recycling endosome pathway at appendages of the mother centriole

Hehnly, H., Chen, C. T., Powers, C. M., Liu, H. L. & Doxsey, S., Oct 23 2012, In : Current Biology. 22, 20, p. 1944-1950 7 p.

Research output: Contribution to journalArticle

Centrioles
centrosomes
Centrosome
centrioles
endosomes
2010
25 Citations (Scopus)

Cdc42 regulates microtubule-dependent golgi positioning

Hehnly, H., Xu, W., Chen, J. L. & Stamnes, M., Aug 1 2010, In : Traffic. 11, 8, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Dyneins
Microtubules
Centrosome
Nocodazole
Capsid Proteins
2009
31 Citations (Scopus)

Retrograde Shiga toxin trafficking is regulated by ARHGAP21 and Cdc42

Hehnly, H., Longhini, K. M., Chen, J. L. & Stamnes, M., Oct 15 2009, In : Molecular Biology of the Cell. 20, 20, p. 4303-4312 10 p.

Research output: Contribution to journalArticle

Shiga Toxin
Secretory Pathway
Endocytosis
Dyneins
Golgi Apparatus
2007
81 Citations (Scopus)

Regulating cytoskeleton-based vesicle motility

Hehnly, H. & Stamnes, M., May 22 2007, In : FEBS Letters. 581, 11, p. 2112-2118 7 p.

Research output: Contribution to journalShort survey

Cytoskeleton
Proteins
Transport Vesicles
Capsid Proteins
Machinery
2006
30 Citations (Scopus)

Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics

Hehnly, H., Sheff, D. & Stamnes, M., Oct 1 2006, In : Molecular Biology of the Cell. 17, 10, p. 4379-4389 11 p.

Research output: Contribution to journalArticle

Shiga Toxin
Microtubules
Secretory Pathway
Recycling
Transferrin