Projects per year
Personal profile
Research Interests
- liquid-liquid phase separation
- protein quality control
- ubiquitin shuttle proteins
- protein structure and dynamics
- NMR spectroscopy
- microscopy
- cell stress
- biomolecular condensates
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Dive into the research topics where Carlos Castaneda is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Deciphering Molecular Mechanisms Underlying Liquid-liquid Phase Separation of Ubiquilin Proteins: CAREER
5/1/18 → 4/30/23
Project: Research project
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Molecular Basis and Effects of Ubiquilin-2 Phase Separation on Association with ALS-linked Proteins
10/1/17 → 9/30/20
Project: Research project
Research output
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Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation
Zheng, T., Galagedera, S. K. K. & Castañeda, C. A., Jul 2021, In: Protein Science. 30, 7, p. 1467-1481 15 p.Research output: Contribution to journal › Article › peer-review
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Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism
Namitz, K. E. W., Zheng, T., Canning, A. J., Alicea-Velazquez, N. L., Castañeda, C. A., Cosgrove, M. S. & Hanes, S. D., Dec 2021, In: Communications Biology. 4, 1, 398.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure, dynamics and functions of UBQLNs: At the crossroads of protein quality control machinery
Zheng, T., Yang, Y. & Castañeda, C. A., 2020, In: Biochemical Journal. 477, 18, p. 3471-3497 27 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Ubiquitin-Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?
Dao, T. P. & Castañeda, C. A., Nov 1 2020, In: BioEssays. 42, 11, 2000036.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner
Dao, T. P., Martyniak, B., Canning, A. J., Lei, Y., Colicino, E. G., Cosgrove, M. S., Hehnly, H. & Castañeda, C. A., Jun 4 2019, In: Structure. 27, 6, p. 937-951.e5Research output: Contribution to journal › Article › peer-review
23 Scopus citations
Press and Media
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Finding Beauty in Cell Stress
Carlos Castaneda & Heidi Hehnly
3/12/20
1 item of Media coverage
Press/Media: Expert Comment
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Understanding 'Disease Mechanisms' of ALS
Carlos Castaneda & Heidi Hehnly
3/12/18
1 item of Media coverage
Press/Media: Expert Comment
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Jordan Barrett, Maizy Ludden Named Goldwater Scholars
Joseph Paulsen, James T Spencer, Carlos Castaneda, Kari Segraves, Joseph Richard Welsh, Jay Hubisz & Stephan Martin Wehrli
5/1/17
1 item of Media coverage
Press/Media: Expert Comment