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Proteins Medicine & Life Sciences
Ubiquitin Chemical Compounds
Polyubiquitin Chemical Compounds
Lysine Chemical Compounds
Water Medicine & Life Sciences
Micrococcal Nuclease Medicine & Life Sciences
Labeling Chemical Compounds
Nuclear magnetic resonance Chemical Compounds

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Projects 2014 2017

Research Output 2003 2017

  • 883 Citations
  • 14 h-Index from Scopus
  • 28 Article
1 Citations

Functional tuning of the catalytic residue pKa in a de novo designed esterase

Hiebler, K., Lengyel, Z., Castañeda, C. A. & Makhlynets, O. V. 2017 (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Research - peer-reviewArticle

Esterases
Histidine
Tuning
Electrostatics
Static Electricity
12 Citations

Linkage-specific conformational ensembles of non-canonical polyubiquitin chains

Castañeda, C. A., Chaturvedi, A., Camara, C. M., Curtis, J. E., Krueger, S. & Fushman, D. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5771-5788 18 p.

Research output: Research - peer-reviewArticle

Polyubiquitin
linkages
Lysine
Conformations
Crystal structure
12 Citations

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins

Castañeda, C. A., Dixon, E. K., Walker, O., Chaturvedi, A., Nakasone, M. A., Curtis, J. E., Reed, M. R., Krueger, S., Cropp, T. A. & Fushman, D. Mar 1 2016 In : Structure. 24, 3, p. 423-436 14 p.

Research output: Research - peer-reviewArticle

Polyubiquitin
Ubiquitin
Lysine
Ubiquitins
Small Angle Scattering
9 Citations

Base-CP proteasome can serve as a platform for stepwise lid formation

Yu, Z., Livnat-Levanon, N., Kleifeld, O., Mansour, W., Nakasone, M. A., Castaneda, C. A., Dixon, E. K., Fushman, D., Reis, N., Pick, E. & Glickman, M. H. 2015 In : Bioscience Reports. 35, e00194

Research output: Research - peer-reviewArticle

Proteasome Endopeptidase Complex
ATP dependent 26S protease
Holoenzymes
Eukaryota
Peptide Hydrolases
14 Citations

DNA-damage-inducible 1 protein (Ddi1) contains an uncharacteristic ubiquitin-like domain that binds ubiquitin

Nowicka, U., Zhang, D., Walker, O., Krutauz, D., Castañeda, C. A., Chaturvedi, A., Chen, T. Y., Reis, N., Glickman, M. H. & Fushman, D. Mar 3 2015 In : Structure. 23, 3, p. 542-557 16 p.

Research output: Research - peer-reviewArticle

Ubiquitin
DNA Damage
Proteins
Saccharomyces cerevisiae Proteins
Protein Transport