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Carlos Castaneda

  • 969 Citations
  • 15 h-Index
20032023
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Ubiquitin Medicine & Life Sciences
Polyubiquitin Chemical Compounds
Proteins Medicine & Life Sciences
Lysine Chemical Compounds
Micrococcal Nuclease Medicine & Life Sciences
Proteasome Endopeptidase Complex Medicine & Life Sciences
Water Medicine & Life Sciences
Telomere Medicine & Life Sciences

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Projects 2014 2023

Deciphering Molecular Mechanisms Underlying Liquid-liquid Phase Separation of Ubiquilin Proteins: CAREER

Castaneda, C.

National Science Foundation

5/1/18 → 4/30/23

Project: Research project

Molecular Basis and Effects of Ubiquilin-2 Phase Separation on Association with ALS-linked Proteins

Castaneda, C.

ALS Association

10/1/17 → 9/30/20

Project: Research project

Effects of Ubiquilin-2 ALS Mutations on Structure, Dynamics, and Interactions With Other ALS-Associated Proteins

Castaneda, C.

Amyotrophic Lateral Sclerosis Association (ALS)

8/1/16 → 7/31/17

Project: Research project

Utilization of a Shimadzu Triple-Quad to Address Critical Questions Pertaining to Peptide and Protein Post-Translational and Chemical Modifications

Castaneda, C. & Doyle, R. P.

Shimadzu Scientific Instruments

7/1/14 → 6/30/15

Project: Research project

Research Output 2003 2018

  • 969 Citations
  • 15 h-Index
  • 30 Article

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions

Dao, T. P., Kolaitis, R-M., Kim, H. J., O'Donovan, K., Martyniak, B., Colicino, E., Hehnly, H., Taylor, J. P. & Castañeda, C. A. Mar 15 2018 In : Molecular Cell. 69, 6, p. 965-978.e6

Research output: Contribution to journal › Article

RNA-Binding Proteins
Ubiquitin
Polyubiquitin
Organelles
Proteins
1 Citations

Functional tuning of the catalytic residue pKa in a de novo designed esterase

Hiebler, K., Lengyel, Z., Castañeda, C. A. & Makhlynets, O. V. 2017 (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journal › Article

Esterases
Histidine
Tuning
Static Electricity
Electrostatics
1 Citations

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

Nakasone, M. A., Lewis, T. A., Walker, O., Thakur, A., Mansour, W., Castañeda, C. A., Goeckeler-Fried, J. L., Parlati, F., Chou, T. F., Hayat, O., Zhang, D., Camara, C. M., Bonn, S. M., Nowicka, U. K., Krueger, S., Glickman, M. H., Brodsky, J. L., Deshaies, R. J. & Fushman, D. Dec 5 2017 In : Structure. 25, 12, p. 1839-1855.e11

Research output: Contribution to journal › Article

Proteasome Endopeptidase Complex
Ubiquitin
Polyubiquitin
Ubiquitination
Protein Binding
14 Citations

Linkage-specific conformational ensembles of non-canonical polyubiquitin chains

Castañeda, C. A., Chaturvedi, A., Camara, C. M., Curtis, J. E., Krueger, S. & Fushman, D. 2016 In : Physical Chemistry Chemical Physics. 18, 8, p. 5771-5788 18 p.

Research output: Contribution to journal › Article

Polyubiquitin
linkages
Lysine
Conformations
Crystal structure
13 Citations

Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins

Castañeda, C. A., Dixon, E. K., Walker, O., Chaturvedi, A., Nakasone, M. A., Curtis, J. E., Reed, M. R., Krueger, S., Cropp, T. A. & Fushman, D. Mar 1 2016 In : Structure. 24, 3, p. 423-436 14 p.

Research output: Contribution to journal › Article

Polyubiquitin
Ubiquitin
Lysine
Ubiquitins
Small Angle Scattering

Press and Media

Understanding 'Disease Mechanisms' of ALS

Carlos Castaneda

3/12/18

1 item of media coverage

Press/Media: Expert Comment

Jordan Barrett, Maizy Ludden Named Goldwater Scholars

Joseph Paulsen, James T Spencer, Carlos Castaneda, Kari Segraves, Joseph Richard Welsh, Jay Hubisz & Stephan Martin Wehrli

5/1/17

1 item of media coverage

Press/Media: Expert Comment