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Personal profile

Research Interests

  • liquid-liquid phase separation
  • protein quality control
  • ubiquitin shuttle proteins
  • protein structure and dynamics
  • NMR spectroscopy
  • microscopy
  • cell stress
  • biomolecular condensates

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Projects

Research Output

Ubiquitin-Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?

Dao, T. P. & Castañeda, C. A., 2020, (Accepted/In press) In : BioEssays.

Research output: Contribution to journalReview article

  • ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

    Dao, T. P., Martyniak, B., Canning, A. J., Lei, Y., Colicino, E. G., Cosgrove, M. S., Hehnly, H. & Castañeda, C. A., Jun 4 2019, In : Structure. 27, 6, p. 937-951.e5

    Research output: Contribution to journalArticle

  • 14 Scopus citations

    Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

    Caselle, E. A., Yoon, J. H., Bhattacharya, S., Rempillo, J. J. L., Lengyel, Z., D'Souza, A., Moroz, Y. S., Tolbert, P. L., Volkov, A. N., Forconi, M., Castañeda, C. A., Makhlynets, O. V. & Korendovych, I. V., Mar 6 2019, In : ChemCatChem. 11, 5, p. 1377 1 p.

    Research output: Contribution to journalComment/debate

  • Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

    Caselle, E. A., Yoon, J. H., Bhattacharya, S., Rempillo, J. J. L., Lengyel, Z., D'Souza, A., Moroz, Y. S., Tolbert, P. L., Volkov, A. N., Forconi, M., Castañeda, C. A., Makhlynets, O. V. & Korendovych, I. V., Mar 6 2019, In : ChemCatChem. 11, 5, p. 1425-1430 6 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Phase separation in biology and disease—a symposium report

    Cable, J., Brangwynne, C., Seydoux, G., Cowburn, D., Pappu, R. V., Castañeda, C. A., Berchowitz, L. E., Chen, Z., Jonikas, M., Dernburg, A., Mittag, T. & Fawzi, N. L., Sep 1 2019, In : Annals of the New York Academy of Sciences. 1452, 1, p. 3-11 9 p.

    Research output: Contribution to journalComment/debate

  • 3 Scopus citations

    Press and Media

    Finding Beauty in Cell Stress

    Carlos Castaneda & Heidi Hehnly

    3/12/20

    1 item of Media coverage

    Press/Media: Expert Comment

    ASBMB Today March 2019

    Carlos Castaneda

    3/12/19

    1 item of Media coverage

    Press/Media: Expert Comment

    Understanding 'Disease Mechanisms' of ALS

    Carlos Castaneda & Heidi Hehnly

    3/12/18

    1 item of Media coverage

    Press/Media: Expert Comment