Projects per year
Personal profile
Research Interests
- liquid-liquid phase separation
- protein quality control
- ubiquitin shuttle proteins
- protein structure and dynamics
- NMR spectroscopy
- microscopy
- cell stress
- biomolecular condensates
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 5 Finished
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The Role and Mechanisms of UBQLN2-mediated Phase Transitions in the Assembly and Disassembly of Biomolecular Condensates
Castaneda, C. (PI)
4/1/20 → 1/31/25
Project: Sponsored Project
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Deciphering Molecular Mechanisms Underlying Liquid-liquid Phase Separation of Ubiquilin Proteins: CAREER
Castaneda, C. (PI)
5/1/18 → 4/30/24
Project: Sponsored Project
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Molecular Basis and Effects of Ubiquilin-2 Phase Separation on Association with ALS-linked Proteins
Castaneda, C. (PI)
10/1/17 → 3/31/21
Project: Sponsored Project
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Effects of Ubiquilin-2 ALS Mutations on Structure, Dynamics, and Interactions With Other ALS-Associated Proteins
Castaneda, C. (PI)
8/1/16 → 7/31/17
Project: Sponsored Project
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Utilization of a Shimadzu Triple-Quad to Address Critical Questions Pertaining to Peptide and Protein Post-Translational and Chemical Modifications
Castaneda, C. (PI) & Doyle, R. P. (CoI)
7/1/14 → 6/30/15
Project: Sponsored Project
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Protein quality control machinery: regulators of condensate architecture and functionality
Rajendran, A. & Castañeda, C. A., Feb 2025, In: Trends in Biochemical Sciences. 50, 2, p. 106-120 15 p.Research output: Contribution to journal › Review article › peer-review
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Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity
Safren, N., Dao, T. P., Mohan, H. M., Huang, C., Trotter, B., Castañeda, C. A., Paulson, H., Barmada, S. & Sharkey, L. M., Dec 2024, In: Scientific reports. 14, 1, 6049.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate
Valentino, I. M., Llivicota-Guaman, J. G., Dao, T. P., Mulvey, E. O., Lehman, A. M., Galagedera, S. K. K., Mallon, E. L., Castañeda, C. A. & Kraut, D. A., Aug 13 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 33, e2405964121.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation
Dao, T. P., Rajendran, A., Galagedera, S. K. K., Haws, W. & Castañeda, C. A., Jun 4 2024, In: Biophysical Journal. 123, 11, p. 1449-1457 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Vimentin is a key regulator of cell mechanosensing through opposite actions on actomyosin and microtubule networks
Alisafaei, F., Mandal, K., Saldanha, R., Swoger, M., Yang, H., Shi, X., Guo, M., Hehnly, H., Castañeda, C. A., Janmey, P. A., Patteson, A. E. & Shenoy, V. B., Dec 2024, In: Communications Biology. 7, 1, 658.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Press and Media
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NSF Grant in Biology Aims to Boost STEM Student Retention Through Hands-On Research
Coleman, H., Castaneda, C., Hehnly, H. & Finkelstein, E.
10/29/24
2 items of Media coverage
Press/Media: Expert Comment
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BioInspired Wins NSF Grant to Develop Graduate Training Program in Emergent Intelligence
Brown, D., Castaneda, C., Zhang, T., Ma, Z., Hehnly, H. & Agnew, L.
8/26/24
1 item of Media coverage
Press/Media: Expert Comment
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BioInspired Wins NSF Grant to Develop Graduate Training Program in Emergent Intelligence
Brown, D., Castaneda, C., Zhang, T., Ma, Z., Hehnly, H. & Agnew, L.
8/26/24
1 item of Media coverage
Press/Media: Expert Comment
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See the speaker lineup for #DiscoverBMB interest groups
1/11/24
1 item of Media coverage
Press/Media: Expert Comment
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Unraveling Protein Control: A New Frontier in Neurodegenerative Disease Research
11/14/23
1 item of Media coverage
Press/Media: Expert Comment