Projects per year
Personal profile
Research Interests
- liquid-liquid phase separation
- protein quality control
- ubiquitin shuttle proteins
- protein structure and dynamics
- NMR spectroscopy
- microscopy
- cell stress
- biomolecular condensates
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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The Role and Mechanisms of UBQLN2-mediated Phase Transitions in the Assembly and Disassembly of Biomolecular Condensates
4/1/20 → 1/31/25
Project: Sponsored Project
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Deciphering Molecular Mechanisms Underlying Liquid-liquid Phase Separation of Ubiquilin Proteins: CAREER
5/1/18 → 4/30/24
Project: Sponsored Project
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Molecular Basis and Effects of Ubiquilin-2 Phase Separation on Association with ALS-linked Proteins
10/1/17 → 3/31/21
Project: Sponsored Project
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Effects of Ubiquilin-2 ALS Mutations on Structure, Dynamics, and Interactions With Other ALS-Associated Proteins
8/1/16 → 7/31/17
Project: Sponsored Project
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Utilization of a Shimadzu Triple-Quad to Address Critical Questions Pertaining to Peptide and Protein Post-Translational and Chemical Modifications
7/1/14 → 6/30/15
Project: Sponsored Project
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A Spectrophotometric Turbidity Assay to Study Liquid-Liquid Phase Separation of UBQLN2 In Vitro
Raymond-Smiedy, P., Bucknor, B., Yang, Y., Zheng, T. & Castañeda, C. A., 2023, Methods in Molecular Biology. Humana Press Inc., p. 515-541 27 p. (Methods in Molecular Biology; vol. 2551).Research output: Chapter in Book/Entry/Poem › Chapter
1 Scopus citations -
Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid-Liquid Phase Separation
Robb, C. G., Dao, T. P., Ujma, J., Castañeda, C. A. & Beveridge, R., Jun 14 2023, In: Journal of the American Chemical Society. 145, 23, p. 12541-12549 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units
Galagedera, S. K. K., Dao, T. P., Enos, S. E., Chaudhuri, A., Schmit, J. D. & Castañeda, C. A., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 42, e2306638120.Research output: Contribution to journal › Article › peer-review
Open Access -
We con-dense if we want to; We can't leave AZUL outside
Dao, T. P. & Castañeda, C. A., Apr 6 2023, In: Structure. 31, 4, p. 369-371 3 p.Research output: Contribution to journal › Comment/Debate/Erratum › peer-review
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Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains
Dao, T. P., Yang, Y., Presti, M. F., Cosgrove, M. S., Hopkins, J. B., Ma, W., Loh, S. N. & Castañeda, C. A., Aug 3 2022, In: EMBO Reports. 23, 8, e55056.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations
Press and Media
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Unraveling Protein Control: A New Frontier in Neurodegenerative Disease Research
11/14/23
1 item of Media coverage
Press/Media: Expert Comment
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The Goldilocks Effect: Syracuse researchers establish framework for protein regulation
11/13/23
2 items of Media coverage
Press/Media: Expert Comment
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Interest group sessions for your #DiscoverBMB itinerary
11/2/23
1 item of Media coverage
Press/Media: Expert Comment
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Findings in Ubiquitin Reported from Syracuse University (Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units)
10/27/23
1 item of Media coverage
Press/Media: Expert Comment
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